1
Q
What is it?
A
SLE: Systemic Lupus Erythematosus
- Causes a huge and varied auto antibody response
- Multiorgan involvement
2
Q
SYmptoms
A
- Butterfly rash on face, African American
- rash over whole body,
- vasoconstriction of fingers = white
- joint pain, arthritis, renal disease, blood disorders
- Baldness, oral ulcers
3
Q
diagnosis
A
need at least 4 symptoms
4
Q
medications that can cause it
A
Hydralazine, lithium, carbamazepine, phenytoin, sulfasalazine simvastatin, hydrochlorothiazide, propylthiouracil, chlorpromazine
5
Q
Azathioprine
MOA
A
Purine Antimetabolite
-Prevents formation of adenylic and guanylic acids from iosinic acid
6
Q
Mycophenolate
A
Uncompetitively and reversibly inhibits IMPDH
-blocks purine synthesis
