1
Q
Secreted proteins in Innate immunity
A
- Lysozyme
- Complement
- CRP
- Defensins
2
Q
HLA-A3 disease
A
Hemochromatosis
3
Q
HLA-B27 Diseases
PAIR
A
- Psoriatic arthritis
- Ankylosing spondylitis
- Inflammatory bowel disease arthritis
- Reactive artheritis (Reiter syndrome)
4
Q
HLA-DQ2/DQ8 disease
A
Celiac
5
Q
HLA-DR2 disease
A
- MS
- Hay fever
- Goodpasture
- SLE
6
Q
HLA-DR3 disease
A
- DM type 1
- SLE
- Graves
7
Q
HLA-DR4 disease
A
RA
DM type 1
8
Q
HLA-DR5 disease
A
Pernicious anemia: B12 deficiency
Hashimoto
9
Q
SLE HLA
A
DR2
DR3
10
Q
DM type 1 HLA
A
DR3
DR4
11
Q
NK cells enhanced by
A
- IL-2
- IL-12
- IFN-β
- IFN-α
12
Q
Acute-phase reactants induced by
A
- IL-6
- IL-1
- TNF-α
- IFN-γ
13
Q
C1 esterase inhibitor deficiency causes
A
Hereditary angioedema
ACE inhibitors are contraindicated
14
Q
DAF deficiency causes
A
Complement-mediated lysis of RBC
Paroxysmal nocturnal hemoglobinuria
15
Q
Hot T-Bone stEAK
A
- IL-1: fever (hot)
- IL-2: stimulates T cells
- IL-3: stimulates Bone marrow
- IL-4: stimulates IgE production
- IL-5: stimulates IgA production
- IL-6: stimulates aKute-phase protein
16
Q
Cytokines secreated by macrophages
A
- IL-1
- IL-6
- IL-8
- IL-12
- TNF-α
17
Q
IL-12 induces
A
Differentiation of T cells into Th1 cells
Activates NK cells
18
Q
TNF-α action
A
- Mediates septic shock
- Activates endothelium
- Causes leukocyte recruitment
19
Q
Cytokines secreted by T cells
A
IL-2
IL-3
20
Q
Th1 cells secrete
A
IFN-γ
21
Q
Myasthenia autoAB
A
Anti-ACh receptor
22
Q
Goodpasture AutoAB
A
Anti-BM
23
Q
SLE AutoAB
A
Anti-cardiolipin
Anti-dsDNA
anti-Smith
ANA
24
Q
Type 1 DM AutoAB
A
Anti-glutamate decarboxylase
25
Bruton agammaglobulinemia defect
X-linked defectin BTK leading to no B cell maturation
26
T-cell disorders (**4**)
1. DiGeorge
2. IL-12 receptor deficiency
3. Job syndrome (**Hyper-IgE**)
4. Chronic mucocutaneous candidiasis
27
IL-12 receptor deficiency is
AR causes decrease Th1 response
28
Job syndrome aka
AD hyper-IgE syndrome
29
Job syndrome is **FATED**
1. Coarse **F**ace
2. **A**bscess due to Staph
3. Primary **T**eeth retained
4. Ig**E** increased
5. **D**ermatologic
30
Job syndrome due to
STAT3 mutation causing TH17 deficiency
31
Ataxia-telangiectasia is a defect in
ATM leading to DNA double strand break and causes cell cycle to arrest
32
Ataxia-telangiectasia triad
Ataxia
Spider Angioma
IgA deficiency
33
Wiskott-Aldrich syndrome is a mutation
X-linked recessive mutation in WAS gene leading to T cells unable to reorganize actin cytoskeleton
34
Wiskott-Aldrich is **WATER**
1. **W**iskott-**A**ldrich
2. **T**hrombocytopenic purpura
3. **E**czema
4. **R**ecurrent
35
Chédiak-Higashi defect is
AR defect in **Lysosomal** **trafficking** **regulator** **gene** causing microtubule dysfunction in phagosome-lysosome fusion
36
Chédiak-Higashi syndrome clinical
1. Recurrent pyogenic infections
2. Albinism
3. Peripheral neuropathy
4. Progressive neurodegeneration
37
Cyclosporine MOA
1. Calcineurin inhibitor
2. Binds cyclophilin
3. Bloks T-cell activation by preventing IL-2 transcription
38
Cyclosporine toxicity (**7**)
1. Nephrotoxic
2. HT
3. Hyperlipidemia
4. Hyperglycemia
5. Tremor
6. Hirsutism
7. Gingival hyperplasia
39
Tacrolimus MOA
1. Calcineurin inhibitor
2. Binds FK506 binding protein
3. Blocks T cell activation by preventing IL-2 transcription
40
Sirolimus aka
Rapamycin
41
Sirolimus MOA
1. mTOR inhibitor
2. Blocks T cell activation and B cell differention by preventing IL-2 signal tranduction
42
What immunosuppressant used in Kidney transplant
Sirolimus
43
Basilizimab is
Monoclonal AB that blocks IL-2R
44
Azathioprine MOA
1. Precursor of 6-MP
2. Inhibits lymphocyte proliferation by blocking nucleotide synthesis
45
AB used for cancer therapy (**5**)
1. Alemtuzumab
2. Bevacizumab
3. Cetuximab
4. Rituximab
5. Trastuzumab
46
Alemtuzumab targets
CD52 used for CLL
47
Bevacizumab targets
VEGF used for colorectal and renal cell carcinoma
48
Cetuximab target
EGFR for Stage 4 colorectal cancer and Head and neck cancer
49
Rituximab target
CD20 for B-cell lymphoma, RA and ITP
50
Trastuzumab target
HER2/neu
51
AB used for Autoimmune diease (**3**)
1. Infliximab
2. Adalimumab
3. Natalizumab
52
What antibody targets TNF-α in RA
1. Infliximab
2. Adalimumab
53
Natalizumab targets
α4-integrin used for multiple sclerosis and Crohns
54
Abciximab target
Glycoprotein 2b/3a
55
Denosumab targets
RANKL in osteoporosis
56
Omalizumab targets
IgE in asthma
57
Palivizumab target
RSV F protein
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