1
Q
Km is
A
inversely related to the affinity
2
Q
Vmax is
A
Directly proportional to enzyme concentration
3
Q
Increase y-intercept on Lineweaver-Burk plot means
A
Decrease in Vmax
4
Q
Competitive inhibiotrs do what on a Lineweaver-Burk plot
A
Bring Km closer to 0
No change to Vmax (y-intercept)
5
Q
Bioavailability (F)=
A
AUCo / AUCIV
6
Q
Volume of distribution (Vd) =
A
Dose / [P]
7
Q
Drug with low Vd found in
A
Blood
8
Q
Drug with medium Vd found in
A
ECF
9
Q
Drug with High Vd found in
A
All tissues
10
Q
t1/2=
A
[0.7 X Vd] / Cl
11
Q
Cl=
A
Rate of elimination / [P]
Vd X K
12
Q
Loading dose=
A
[Cp x Vd] / F
13
Q
Maintenance dose=
A
[Cp x Cl x τ] / F
14
Q
Zero PEAs for me
A
Drugs with zero order of elimination
- Phenytoin
- Ethanol
- Asprin
15
Q
Phase 1 drug metabolism
A
- Reduction
- Oxidation
- Hydrolysis with P-450
16
Q
Phase 2 drug metabolism
A
- Glucuronidation
- Acetylation
- Sulfation
17
Q
Efficacy is
A
Maximal effect a drug can produce
18
Q
Potency is
A
Amount of drug needed for a given effect
19
Q
α1 major functions
A
- Gq
- Increase vascular smooth muscle contraction
- Increase pupillary dilator muslce contraction (Mydriasis)
- Increase intestinal and bladder sphincter muscle contraction
20
Q
α2 major function
A
- Gi
- Decrease symathetic outflow
- Decrease insulin release
- Decrease lipolysis
- Increase Platelet aggregation
21
Q
Hemicholinium action
A
Inhibits Choline uptake
22
Q
Vesamicol action
A
Inhibits ACh storage
23
Q
Botulinum action
A
Inhibit ACh release
24
Q
Metyrosine action
A
Inhibit formation of DOPA from Tyrosine
25
Reserpine action
Inhibit storage of NE
26
Bretylium action
Inhibits release of NE
27
Amphetamine action
Increase release of NE
28
Cocaine and TCA action
Inhibit reuptake of NE
29
Cholinomimetic direct agonists
1. Bethanechol
2. Carbachol
3. Pilocarpine
4. Methacholine
30
Bethanechol clinical use
1. Post-op ileus
2. Neurologenic ileu
3. Urinary retention
31
Pilocarpine used for
Open-angle and closed-angle glaucoma
32
Methacholine used for
Challenge test for diagnosis of asthma
33
Anticholinesterases (**7**)
1. Neostigmine
2. Pyridostigmine
3. Physostigmine
4. Donepezil
5. Rivastigmine
6. Galantamine
7. Edrophonium
34
Neostigmine used for
1. Post-op and neurogenic ileus
2. Urinary retention
3. Myasthenia gravis
4. Reversal of NMJ block
35
Long acting drug for Myasthenia gravis
Pyridostigmine
36
Used for Atropine overdose
Physostigmine
37
DRG for Alzheimers
Donepezil
Rivastigmine
Galantamine
38
Muscarinic antagonist used for Parkinson disease
Benztropine
39
Muscarinc antagonist used for COPD and asthma
Ipratropium
Tiotropium
40
Muscarinic antagonist used to reduce urgency and reduce bladder spasms
Oxybutynin
Dari**fenacin**
Soli**fenacin**
41
Isproterenol action
β1=β2 direct sympathomimetic
42
Phenylephrine action
α1\>α2 direct sympathomimetic
43
What direct sympathomimetic is used for long-term asthma or COPD
Salmeterol
44
What direct sympathomimetic used to reduce premature uterine contraction
Terbutaline
45
Nonselective α blocker
Phenoxybenzamine (**irreversible**)
Phentolamine (**reversible**)
46
What is the treatment for Pheochromocytoma
Phenoxybenzamine
47
α2 selective blocker
Mirtazapine used for depression
48
β-blockers used for MI
1. Metoprolol
2. Carvedilol
3. Bisoprolol
49
β-blocker used for Glaucoma
Timolol
50
β-blocker used for SVT
Metoprolol
Esmolol
51
Nonselective α and β antagonist
Carvedilol
Labetalol
52
Partial β-agonist
Acebutolol
Pindolol
53
**VANC** causes cutaneous flushing
* **V**ancomycin
* **A**denosine
* **N**iacin
* **C**a channel blockers
54
Drugs causing Torsades
1. Class 3 and Class 1A antiarrhythmics
2. macrolide
3. Antipsychotics
4. TCA
55
Drugs causing Hyperglycemia (**6**)
1. Tacrolimus
2. Protease inhibitor
3. Niacin
4. HCTZ
5. β-blockers
6. Corticosteroids
56
Drugs that **M**ight **E**xcite **C**olon **O**n **A**ccident
* **M**etformin
* **E**rythromycin
* **C**olchicine
* **O**rlistat
* **A**carbose
57
**D**rugs **C**ausing **A** **V**iolent **A**bdominal **D**istress causes Pancreatitis
* **D**idanosine
* **C**orticosteroids
* **A**lcohol
* **V**alproic acid
* **A**zathioprine
* **D**iuretics
58
What drugs cause Agranulocytosis (**6**)
1. Dapsone
2. Clozapine
3. Carbamazepine
4. Colchicine
5. Methimazole
6. Propylthiouracil
59
What drugs cause Aplastic anemia (**6**)
1. Carbamazepine
2. Methimazole
3. NSAIDs
4. Benzene
5. Chloramphenicol
6. Propylthiouracil
60
Drugs causing Hemolysis in G6PD deficiency
## Footnote
**IS D PAIN**
1. **I**NH
2. **S**ulfonamide
3. **D**apsone
4. **P**rimaquine
5. **A**sprin
6. **I**buprofen
7. **N**itrofurantoin
61
Drugs causing Megaloblastic anemia
Phenytoin
Methotrexate
Sulfa drugs
62
Drugs cuasing gout (**5**)
1. Pyrazinamide
2. Thiazide
3. Furosemide
4. Niacin
5. Cyclosporine
63
Drugs causing photosensitivity
1. Sulfonamide
2. Amiodarone
3. Tetracyclines
4. 5-FU
64
Drugs causing SLE-like syndrome
## Footnote
**SHIPPE-E**
* **S**ulfa
* **H**ydralazine
* **I**NH
* **P**rocainamide
* **P**henytoin
* **E**tanercept
65
Drugs causing Seizures (**6**)
1. INH
2. Bupropion
3. Impenem/cilastatin
4. Tramadol
5. Enflurane
6. Metoclopramide
66
**Chronic Alcohol**ic **Mo**na **St**eals **Phen**-**Phen** and **Ne**ver **R**efuses **Gr**easy **Carb**s are P-450 inducers
1. **Chronic alcohol**
2. **Mo**dafinil
3. **St**. John's wort
4. **Phen**ytoin
5. **Phen**obarbital
6. **Ne**virapine
7. **R**ifampin
8. **Gri**seofluvin
9. **Carb**amazepine
67
**A cute** **Ge**ntileman **Cip**ped **I**ced **Grapefruit juice** **Qui**ckly **A**nd **Ke**pt **M**unching on **S**oft **C**inammon **R**olls are P-450 inhibitors
1. **Acute** alcohol
2. **Ge**mfibrozil
3. **Ci**profloxacin
4. **I**soniazid
5. **Grapefruit juice**
6. **Qu**inidine
7. **A**miodarone
8. **Ke**toconazole
9. **M**acrolides
10. **S**ulfonamides
11. **C**imetidine
12. **R**itonavir
68
Sulfa drugs (**8**)
1. Probenecid
2. Furosemide
3. Acetazolamide
4. Celecoxib
5. Thiazide
6. Sulfonamide
7. Sulfasalazine
8. Sulfonylurea
69
-bendazole are
Antiparasitic/antihelmintic
70
-ivir are
Neuraminidase inhibitor
71
-navir are
Protease inhibitor
72
-ovir are
DNA polymerase inhibitor
73
-ane are
Inhalational general anesthetic
74
-azine are
Typical antipsychotic
75
-etine are
SSRI
76
-ipramine are
TCA
77
-triptan are
seratonin agonist
78
-triptyline are
TCA
79
-afil are
PDE-5 inhibitor
80
-sartan are
Angiotensin-2 receptor blocker
81
-dronate are
Bisphosphonate
82
-glitazone are
PPAR-γ activator
83
-prost are
Prostaglandin analog
84
-tidine are
H2-antagonists
First Aid
flashcards
Decks in class (16)
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