Intermediate Filament Markers

Question 1

Identify tumors derived from smooth, cardiac &
skeletal muscles

Answer 1

Actin

Question 2

Present in normal mesenchymal cells and their neoplastic counterparts:

Answer 2

Vimentin

Question 3

Neoplastic counterparts: (5)

Answer 3

1. Sarcoma
2. Melanoma
3. Leukemia
4. Seminoma
5. Schwannomas (cancer in schwann cells)

Question 4

Highly specific for myogenic tumors

Answer 4

Desmin

Question 5

Confirms diagnosis of astrocytoma

Answer 5

Glial fibrillary acidic protein (GFAP)