1
Q
What are some advantages of IV infusion?
A
- precise control of blood drug concentration
- excellent for narrow therapeutic drugs (eliminates wide fluctuations between peak and trough levels)
- duration can be terminated as needed
2
Q
At ____ _____: rate of drug input (infusion rate) = rate of drug output (elimination rate)
A
steady state
3
Q
IV follows ___- compartment model
A
one
4
Q
R = ?
A
infusion rate
5
Q
k = ?
A
elimination rate
6
Q
DB = ?
A
amount of drug in body
7
Q
Approximately how many half lives will ensure 90% of drug has left the body?
A
3
8
Q
Time to reach SS (steady state) depends on ??
A
T1/2
9
Q
Does increasing the rate of infusion shorten the time to reach SS?
A
NO - Increasing rate of insulin does NOT shorten the time to reach SS
10
Q
What does increasing the rate of infusion affect?
A
it affects the final concentration
Pharmacokinetics
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