PK 3

Question 1

Ke = ?

Answer 1

urinary excretion rate

Question 2

Knr = ?

Answer 2

non-renal excretion

Question 3

What is the formula for K?

Answer 3

K = Ke + Knr

Question 4

What are the 2 methods for determining the amount of drug excreted in urine?

Answer 4

1) t* method

2) sigma-minus method

Question 5

What are some problems in obtaining valid urinary excretion data?

Answer 5

• significant fraction excreted unchanged
• specific assay
• frequent sampling
• long sampling time
• variations in pH and volume affects excretion rates
• complete urine specimen required (i.e. if they have an empty bladder = problem)