KELL BGS

Question 1

1. ISBT SYMBOL
2. ISBT NUMBER
3. ANTIBODY CLASS
4. EFFECT IN ENZYME

Answer 1

1. KEL
2. 006
3. IgG
4. No effect

Question 2

INTRO

1. consist of ____ high&low prevalence antigens
2. first blood group system discovered after introduction of ______
3. chromosome

Answer 2

1. 32
2. ANTIGLOBULIN testing
3. 7

Question 3

KELL ANTIGENS
1. Excluding ABO, this is second only to D in ________
2. NOT DENATURED BY _______
3. DESTROYED BY _______
4. ______ destroys Kell antigens but not Kx
- give 1
5. ______ also destroys Kell antigens

Answer 3

1. immunogenicity
2. ficin & papain
3. trypsin & chymotrypsin
4. thiol- reducing agents
   - 100-200 mM DTT
5. Glycine-acid EDTA

Question 4

KELL ANTIGENS.2
1. detected on fetal RBCs
- as early as
- prevalance
2. detected at 7 weeks
- prevalence
- originally designated as
3. other antigens
- low prevalence
- high prevalence

Answer 4

1. K antigen
   - 10 weeks
   - 9%
2. k antigen
   - 99.8%
   - CELLANO
3. other antigens
   - Kpa, Kpb, Jsa
   - Kpc, Jsb

Question 5

KELL ANTINODIES

_____: most common antibody seen in blood bank outside ABO & Rh
1. most reliable method
2. depressed rsvtivity of this is observed in _____

______: antibodies to low-prevalence Kell antigens are rare because so few people are EXPOSED to these antigens

______: antibodies to low-prevalence Kell antigens are rare because so few people LACK these antigens

Answer 5

Anti-K
1. IAT
2. Low Ionic Strength Solutions

Antibodies to Kpa, Jsa, and Other Low-Prevalence Kell Antigens

Antibodies to k, Kpb, Jsb, and Other High-Prevalence Kell Antigens

Question 6

ASSOCIATED Kx antigen
1. ISBT #
2. Symbol
3. present on all RBCs except those of rare ____^^^^
4. ____ & _____ phenotype RBCs: have increased Kx antigen
5. red cells w/ _____phenotypes carry trace amounts of Kx antige

Answer 6

1. 019
2. XK
3. Mcleod phenotype
4. Ko & Kmod
5. Normal Kell

Question 7

1. lack expression of all Kell antigens (K null)
2. Immunized individuals w/ K null make antibody called _____ (___)
   - this is ____

Answer 7

1. Ko
2. anti-Ku (K5)
   - IgG

Question 8

________: very rare and is seen almost exclusively in males
1. lack ___ & _____
2. have this cell causing decreased deformability
3. have chronic but well compensated ___^^
4. associated w/ ______
- inability to phagocytes _____
- enzyme important in generating ________
5. elevated _______ & _________

Answer 8

McLeod Phenotype
1. Kx & Km
2. acanthocytic (spur cell)
3. HEMOLYTIC ANEMIA
4. CHRONIC GRANULOMATOUS DISEASE
- NICOTINAMIDE ADENINE DINUCLEOTIDE HYDRIDE OXIDASE
- HYDROGEN PEROXIDE
5. SERUM CREATININE PHOSPHOKINASE LVL OF MM TYPE & CARBONIC ANHYDRASE III LVL