INTRO
1. presence of Lutheran glycoprotein on ______ may result in adsorption of maternal
antibodies to Lutheran antigens
- ____ the likelihood of HDFN
- Placental tissue
- Decreasing
LUTHERAN ANTIGENS
- _____ antigens are part of Lutheran
- detected as early as
- ______ developed at birth
- Lua & Lub: produced by _______
- 20
- 10-12 weeks
- POORLY
- ALLELIC CODOMINANT GENES
Antibodies
________: following the transfusion of unit of blood carrying corresponding low-prevalence antigen; donor’s last name was Lutteran
1. found in serum of patient w/ ______
2. _____: class
3. has characteristic of _______
- _____ are surrounded by _______
anti- Lua
1. LUPUS ERYTHEMATOSUS
2. IGM
3. MIXED AGGLUTINATION
- SMALL AGGLUTINATES; UNAGGLUTINATED
Antibodies
________: mostly IgG, but IgM & IgA antibodies have also been noted
- has been implicated w/ shortened survival of transfused cells & ______
- ____ has not been reported
anti-Lub
1. postransfusion jaundice
2. severe or acute hemolysis
Antibodies
________: rare antibody that reacts w/ all RBCs except Lu(a-b-) RBCs
- manifested w/ _________ phenotype
- inherited ______ - usually _________
anti-Lu3
1. Lu(a-b-)
- silent gene LuLu
2. antiglobulin reactive
Phenotypes
- rarely occurs and may manifest itself in any of the following 3 unique genetic mechanisms
a. only true Lunull phenotype; homozygosity for rare recessive amorph, Lu (LuLu)
- _____ LU locus
b. heterozygosity for rare dominant inhibitor gene, In(Lu),
- _______ at the LU locus
c. inherited in recessive manner
- Lunull/ Lu(a-b-)
a. RECESSIVE
- LOCATED
b. DOMINANT/ In(Lu)
- NOT LOCATED
c. X LINKED SUPPRESSOR GENE
