Lecture 23

Question 1

proteins are continually turned over / recycled : the number and type of proteins is driven by what

Answer 1

strain arising from stress

• this can increase or decrease protein production

Question 2

4 steps to making more protein

Answer 2

1. stress signals activate specific pathways / cascades
2. which activate transcription factors
3. that switch off / on genes to produce code for new proteins
4. proteins made by ribosomes using this code

Question 3

what is a prerequisite for protein synthesis, but why is synthesis not guaranteed

Answer 3

signalling

• also need amino acids to make the protein
• also need the machinery (useable DNA, nuclei, ribosomes)

Question 4

mRNA response in peak hours post exercise, when is this back to baseline and what does this mean

Answer 4

back to baseline by ~24 hours

so, need to repeat an appropriate stress

Question 5

what adaptations to exercise are far more robust and what does this mean

Answer 5

neural adaptations are far more robust

they gain fast and lose slowly

Question 6

the purpose of a stressor is to what and what is this

Answer 6

the purpose of a stressor is to push you outside your comfort = this is a strain

Question 7

what are the strains of exercise that are caused by stress

Answer 7

• mechanical tension
• pH
• temperature
• hypoxia
• cell volume

Question 8

what are the modulators of strain in exercise

Answer 8

• genes
• age
• training status
• clinical status / meds
• nutrients
• motivation and resilience

Question 9

nature and extent of adaptation to exercise depend on many factors, such as

Answer 9

1. exercise parameters (FITT)
2. personal - e.g genes, age, clinical status
3. diet
4. environment