lecture 9b

Question 1

whats TGF (what does it do)

Answer 1

an anti-inflammatory

Question 2

what does a T cell do if its TCR is not engaged in the lymph-nodes

Answer 2

leave the LN through the efferent lymphatics

Question 3

what do Naiive T cells enter the LN through

Answer 3

the HEV (high endothelial venule)

Question 4

where is the LN do T cells sample DCs

Answer 4

the paracortex

Question 5

what helper cell is effective for allergic reactions

Answer 5

Th2

Question 6

Th1 activate what macrophages

Answer 6

classically activated macrophage (M1) to do inflammation and microbial actions

Question 7

Th2 activates what kind of macrophage

Answer 7

alternatively activated macrophages (M2) that would repair (holes made by worms)

Question 8

which Th cell recruit neutrophils to the site of infection

Answer 8

Th17

Question 9

CD8 T cell response is part of what T helper cell subset

Answer 9

Th1

Question 10

CD8 cells kill what

Answer 10

all pathogens that hide inside cells (viruses, tumours, intracellular bacteria)

Question 11

what cell can cross present

Answer 11

dentritic cells

Question 12

Tc1 CTL are activated by what cytokine

Answer 12

IL-12

Question 13

3 transcription factors important for CTL differentiation

Answer 13

T-Bet
Eomes
BLIMP-1

Question 14

what do CTL secrete at the site of infection

Answer 14

IFN-y and TNF

Question 15

extrinsic pathway of CTLs

Answer 15

FASL receptor on CD8 cells binds to the FAS on target cell and activates caspases leading to Apoptosis

Question 16

intrinsic pathway for CTL

Answer 16

CD8 T cells release perforin + granzymes after recognizing antigen on MHC1 - activating caspases

Question 17

what is FAS

Answer 17

a death receptor on cells

Question 18

does the extrinsic pathway require TCR engagement

Answer 18

no

Question 19

is the intrinsic or extrinsic pathway faster

Answer 19

intrinsic