liver

Question 1

what does Obstetric Cholestasis (OC) present as

Answer 1

pruritus (palms/soles), worse at night, no rash. ( itchy)

Question 2

how is obs cholestasis diagnosed

Answer 2

increase total bile salts + ↑ acids (hypercholanemia).

Question 3

what is the tx for obs cholestasis

Answer 3

Ursodeoxycholic acid → reduces bile salts (safe in pregnancy).
deliver no later than 37 weeks

Question 4

what is acute fatty liver of pregnancy

Answer 4

rapid accumulation of fat within the liver cells (hepatocytes), causing acute hepatitis. There is a high risk of liver failure and mortality, for both the mother and fetus.
- usually in third trimester 35-36 weeks
- very rare

Question 5

what are sx of acute fatty liver of preg

Answer 5

jaundice, RUQ pain, nausea, vomiting, malaise.- related to pre eclampsia, very unwell px

Question 6

how is acute fatty liver of preg diagnosed

Answer 6

↑ bilirubin, deranged LFTs, DIC

Question 7

how is acute fatty liver of preg tx

Answer 7

:emergency delivery – must deliver baby.

Question 8

what is a feature of bile acids worrying in preg

Answer 8

they can be teratogenic if in high concentration