MHC

Question 1

List the characteristics of BCRs.

Answer 1

• binds free/soluble antigens
• Iga/b transduce signals via ITAMs

Question 2

List the characteristics of TCRs.

Answer 2

• binds antigen-derived peptide and MHC
• two subunits a/b with a constant and variable region
• peptide source is endogenous or exogenous

Question 3

MHC I is presented on all (____) cells.

Answer 3

nucleated

Question 4

MHC II is presented on all (____) cells.

Answer 4

APCs

Question 5

Peptide binding groove of 8-10 amino acids is which MHC class?
A. MHC I
B. MHC II

Answer 5

A. MHC I

Question 6

MHC I presents bound peptides to (____) and the peptides are derived from (_____) proteins.
A. CD4; endogenous
B. CD4; exogenous
C. CD8; endogenous
D. CD8; exogenous

Answer 6

C. CD8; endogenous

Question 7

Where are peptides in MHC II presented and derived from?

Answer 7

• present to CD4, Thelper cells
• derived from exogenous antigens

Question 8

MHC I leads to the activation of which cell?

Answer 8

T cytotoxic cells

Question 9

MHC expression can change with:

Answer 9

1. Genetic regulatory components: transcription activators (NLRs)
2. Viral interface: shuts down MHC I
3. Cytokine-mediated signaling: TNFa and Type 1 IFNs

Question 10

How are MHC alleles expressed?

Answer 10

• codominantly
• both maternal and paternal MHC genes are expressed in offspring

Question 11

What is MHC restriction?

Answer 11

• TCRs recognize own protein but do not react to their own protein
• if Tcells recognize MHC they expand

Question 12

Where does the source of protein antigens come from in MHC class I?

Answer 12

cytoplasm