gene pool
The sum of all of all the alleles for all the
genes in a population.
* the sum of all the variation that are
passed on to the next generation;
* the greater variation, greater the
chance of surviving.
population
A population is a group of org. that live together in a given area and time
genotype vs phenotype frequency
Genotype Frequency
The proportion of a population with a particular
genotype express as a fraction.
Phenotype Frequency
The proportion of a population with a particulate
phenotype and express as a fraction
ALLELE FREQUENCY
The rate of occurrence of a particular allele in a
population and usually expressed as a decimal.
- Allele no. is twice the no. of individuals since
each gene have two possible alleles.
example calculation
E.g. Mouse population has genotype:
- 72 BB (black mice)
- 96 Bb (black mice)
- 32 bb (white mice)
Black coat is dominant to white coat
Calculation of Genotype (bb) frequency for
white coat:
Total no. of mice = 200
No. of white coat mice = 32
Therefore genotype frequency = 32/200 =
0.16
Expressed as a percentage = 32/200 x 100
= 16%
gene pool calculatiion
Example of Allele
Frequency© 2017 Pearson Education, Inc.
The gene pool comprises all
of the alleles in a population.
A population of 25 hamsters
contains 50 alleles of the coat
color gene (hamsters are
diploid)
If 20 of those 50 alleles code
for black coats, then the
frequency of the black allele is
0.40, or 40% (20/50 = 0.40)
EVOLUTION
The change in genetic
makeup of populations over
generations.
*Once the allele frequency changes
the population is evolving
How do we determine whether a population is evolving?
The Hardy-Weinberg principle is a mathematical model
proposed in 1908 by an English mathematician,
Godfrey H. Hardy, and a German physician, Wilhelm
Weinberg
* Showed that under certain conditions, allele and
genotype frequencies in a population will
remain constant no matter how many
generations pass
equilibrium population
Hardy-Weinberg Principle
Godfrey Hardy and Wilhelm Weinberg (1908)
An equilibrium population is the term used for this hypothetical non-evolving
population in which allele frequencies do not change as long as the following
conditions are met:
Certain conditions are:
1. There must be no mutations
2. There must be no gene flow/migration
3. The population must be very large
4. Mating must be random; no tendency for certain genotypes to mate
with specific other genotypes
5. There can be no natural selection against any of the phenotype.
Violation of one or more of these five conditions may change allele frequencies, and
population will evolve
The Hardy-Weinberg principle enables
Measurement of the variation within a gene
pool;
2. Compare allele frequency at diff. times
If there is no change in allele frequency, then
the population is said to be in Genetic
Equilibrium
However if there is a change in allele
frequency, then one of the conditions is
not being met and are evolving
Hardy-Weinberg Equation
Used to calculate proportion of a population that carries recessive alleles for genetic
conditions
Symbols used are:
p = frequency of dominant al
q = frequency of recessive allele
q = frequency of recessive alleles
Equation # 1: p + q = 1.00 (all the alleles for this trait in a gene pool)
Equation # 2: p2 + 2pq + q2 = 1.00 (all the individuals in a population)
p
2
+2pq+q
2
=1
This refers to individuals (genotypes), not alleles.
p2
p
2
= frequency of AA
2pq
2pq = frequency of Aa
q2
q
2
= frequency of aa
All possible genotypes together make up the entire population, so their frequencies also sum to 1.
✅ This equation is also correct.
look at sample problems
p: Frequency of the Dominant allele (e.g., A)
q: Frequency of the Recessive allele (e.g., a)
p2: Frequency of Homozygous Dominant individuals (AA)
2pq: Frequency of Heterozygous individuals (Aa)
q2: Frequency of Homozygous Recessive individuals (aa)
5 causes of evolutionary change
Hardy-Weinberg equilibrium can be
disturbed by deviations from any of its
five conditions.
There are, predictably, five major causes
of evolutionary change
1. Mutation
2. Gene flow
3. Genetic Drift- Small population
size
4. Nonrandom mating
5. Natural selection
mutations (
A population remains in evolutionary equilibrium only if there are no mutations (changes in DNA sequence)
o Occur when a cell is making a copy of itself during cell division;
May be detected by the body’s repair system;
If not detected, cells that give rise to gametes are passed to offspring and gene pool of population.
o Inherited mutations are rare but important
Mutations arise spontaneously, not as a result of or in anticipation of, environmental necessity.
gene flow
Gene flow between populations changes allele
frequencies.
Movement of alleles from one population to
another;
Movement of individuals between populations;
Alleles can move between populations at certain
stages in the life cycle even if organisms do not
e. g Pollen and seeds from flowering plants can
move and distribute alleles
If bad luck prevents some members of
a population from reproducing, their
alleles will ultimately be removed from
the gene pool
Genetic drift
Genetic drift is the process by which chance events changes the allele frequency.
If bad luck prevents some members of a population from reproducing, their alleles will
ultimately be removed from the gene pool
Occurs rapidly;
Has little effect in very large populations and bigger effect on small populations;
In small populations, genetic drift can result in the complete loss of an allele in only a few generations.
allele change by chance
llele frequencies may change by chance in small populations
— If bad luck prevents some members of a population from
reproducing, their alleles will ultimately be removed from the
gene pool.
Examples of bad luck include:
— Seeds that fall into a pond or parking lot;
— Flowers destroyed by wildfire before pollination;
— Any org. killed by a flood prior to reproducing.
Population Bottleneck and Founder
Effect.
P
Two (2) causes of genetic drift: Population Bottleneck and Founder
Effect.
Population Bottleneck
A population is drastically reduced by a natural catastrophe or
overhunting.
— Only a few individuals are available to contribute genes to
the next generation;
* Rapidly change allele frequencies and reduce genetic
variation
]
The Founder Effect – New population formed by
ONLY a few individuals.
Occurs when a small no. of individuals leave a large
population and establish a new isolated population
By chance, the allele frequencies of founders may differ
from those of the original population;
May not carry all the alleles of the original population
Over time, the new population may exhibit allele
frequencies that differ from the original population;
Occurs in islands;
The Northern Elephant Seal
example of population bottleneck
Hunted almost to extinction in the 1800s and reduced to
only 20 individuals by the 1890s;
A hunting ban allowed the population to increase to
30,000;
Biochemical analysis shows that present-day northern
elephant seals are almost genetically identical;
lack of genetic variation leaves them little flexibility
to evolve if their environmental circumstances
change.
Nonrandom Mating
Individuals in a population may choose mates based on physical and behavioral traits
and prevents ind. With particular phenotypes from breeding.
Play a significant role in evolution because org. seldom mate strictly
randomly.
Some species lack mobility and tend to stay near their birthplace;
Offspring have parents living in the same area and may be
related
sexual reproduction between relatives is called inbreeding
Inbreeding increase no. of individuals that inherit the same alleles
from both parents
Result in homozygous for many genes
Increase in homozygotes can have harmful effects
Increased occurrence of genetic diseases or disorders
nonrandom mating animals
Nonrandom mating in animals can also arise if
individuals have preferences or biases that
influence their choice of mate
Example:
* The snow goose comes in two “color
phases”:
* some snow geese are white, and others are
blue-gray; mate choice is not random, but
based on color
* The birds exhibit a strong tendency to mate
with a partner of the same co
Natural Selection
The process in which individuals with traits that help them survive,
reproduce and leave more offspring than individuals that lack those
traits.
How does Natural Selection Work?
Natural selection stems from unequal reproduction
“Survival of the fittest ” summarize the process that Darwin named natural
selection
Natural selection favors traits that improved survival and
lead to improved reproduction;
A trait that improves survival increase likelihood that
an individual survives long enough to reproduce;
A trait that improves survival may increase an
organism’s life span;
A trait that improves survival may increase no. of
opportunities to reproduce.
Adaptations
Successful phenotypes are those that have the best
adaptations to their particular environment
Adaptations are characteristics that help an individual survive
and reproduce