How are peptide bonds formed?
through a condensation reaction
where does a peptide bond form between two amino acids?
between the N and C of the two aminos
what is a polypeptide?
when many amino acids are joined together by peptide bonds
which enzyme catalyses the formation of polypeptides?
peptidyl transferase
what is the primary structure of a protein?
the sequence of amino acids in a polypeptide chain
what bonds are involved in the primary structure of a protein?
peptide bonds
what are the secondary structures of a protein?
a-helices and b-pleated sheets
what bonds are involved in the secondary structures of a protein?
peptide and hydrogen bonds
what happens to the peptide chain to form a a-helix?
it twists/coils
what happens to the peptide chain to form a b-pleated sheet?
it folds
how is the tertiary structure of a protein achieved?
through the interaction of r groups on different amino acids. the folding and coiling of secondary structure formations brings the r groups close enough to interact and fold further
what 4 interactions can happen between r groups in tertiary protein structures?
what are van Der walls forces?
weak interactions between polar and non-polar r groups
where do disulphide bonds form?
between r groups containing sulphur atoms, between the sulphur atoms
when can a protein from a quaternary structure?
when it has more than one polypeptide chain
what interactions occur in quaternary protein structures?
where do the interactions in quaternary protein structures take place?
between different protein molecules
what is a prosthetic group?
a non-protein molecule (organic or inorganic) that binds tightly, often covalently, to a protein or enzyme
what is a globular protein?
a compact, roughly spherical protein that’s generally water-soluble, folding into a specific 3D shape where hydrophobic (water-fearing) parts tuck inside and hydrophilic (water-loving) parts face outwards
what is a conjugated protein?
a globular protein with a prosthetic group
what is an example of a globular and conjugated protein?
haemoglobin
what is the structure of haemoglobin
what is insulin an example of?
a globular protein (a hormone)
give an example a conjugated protein which is an enzyme
catalase