Mononeuritis Multiplex

Question 1

What does mononeuritis multiplex refer to?

Answer 1

Involvement of two or more non-contiguous peripheral nerves

Initially asymmetrical, with different nerves affected either sequentially or simultaneously.

Question 2

What is a common presentation of mononeuritis multiplex?

Answer 2

Sudden or subacute loss of sensory and motor function in affected nerves

The deficits can become more confluent and symmetrical as the disease progresses.

Question 3

Name a common cause of mononeuritis multiplex.

Answer 3

• Diabetes mellitus
• Vasculitis
• Autoimmune disorders
• Infectious causes
• Sarcoidosis
• Cryoglobulinaemia
• Exposure to toxins
• Rare causes

Each of these conditions can lead to the development of mononeuritis multiplex.

Question 4

Which nerve is commonly involved in mononeuritis multiplex?

Answer 4

Peroneal nerve

Involvement is common in up to 75% of cases, leading to foot drop.

Question 5

What type of pain is often associated with mononeuritis multiplex?

Answer 5

Deep and aching pain, worse at night

Typically located in the lower back, hips, or legs.

Question 6

What is a specific presentation of diabetic mononeuritis multiplex?

Answer 6

Acute, severe, unilateral thigh pain followed by weakness in the quadriceps

This condition also leads to loss of the knee reflex.

Question 7

What are the two main approaches to the treatment of mononeuritis multiplex?

Answer 7

• Addressing the underlying condition
• Managing neuropathic symptoms

Treatment may include physical therapy, orthotics, and medical management.

Question 8

What medications can be used for pain management in mononeuritis multiplex?

Answer 8

• Anticonvulsants (e.g., gabapentin, pregabalin)
• Antidepressants (e.g., amitriptyline, duloxetine)
• Analgesics or opioids in severe cases

These medications help manage neuropathic pain.

Question 9

True or false: IVIG (Intravenous Immunoglobulin) may be used in some cases of mononeuritis multiplex.

Answer 9

TRUE

Especially those related to immune-mediated causes, IVIG may modulate the immune response.

Question 10

What does mononeuritis multiplex refer to?

Answer 10

Involvement of two or more non-contiguous peripheral nerves

Initially asymmetrical, with different nerves affected either sequentially or simultaneously.

Question 11

What is a common presentation of mononeuritis multiplex?

Answer 11

Sudden or subacute loss of sensory and motor function in affected nerves

The deficits can become more confluent and symmetrical as the disease progresses.

Question 12

Name a common cause of mononeuritis multiplex.

Answer 12

• Diabetes mellitus
• Vasculitis
• Autoimmune disorders
• Infectious causes
• Sarcoidosis
• Cryoglobulinaemia
• Exposure to toxins
• Rare causes

Each of these conditions can lead to the development of mononeuritis multiplex.

Question 13

Which nerve is commonly involved in mononeuritis multiplex?

Answer 13

Peroneal nerve

Involvement is common in up to 75% of cases, leading to foot drop.

Question 14

What type of pain is often associated with mononeuritis multiplex?

Answer 14

Deep and aching pain, worse at night

Typically located in the lower back, hips, or legs.

Question 15

What is a specific presentation of diabetic mononeuritis multiplex?

Answer 15

Acute, severe, unilateral thigh pain followed by weakness in the quadriceps

This condition also leads to loss of the knee reflex.

Question 16

What are the two main approaches to the treatment of mononeuritis multiplex?

Answer 16

• Addressing the underlying condition
• Managing neuropathic symptoms

Treatment may include physical therapy, orthotics, and medical management.

Question 17

What medications can be used for pain management in mononeuritis multiplex?

Answer 17

• Anticonvulsants (e.g., gabapentin, pregabalin)
• Antidepressants (e.g., amitriptyline, duloxetine)
• Analgesics or opioids in severe cases

These medications help manage neuropathic pain.

Question 18

True or false: IVIG (Intravenous Immunoglobulin) may be used in some cases of mononeuritis multiplex.

Answer 18

TRUE

Especially those related to immune-mediated causes, IVIG may modulate the immune response.

Question 19

How is the eye affected?

Answer 19

Pupil sparing third nerve palsy

Question 20

What is mononeuritis multiplex associated with?

Answer 20

Diabetes

Question 21

What is mononeuritis multiplex associated with?

Normal protein and glucose, lymphocyte predominant

Answer 21

Systemic vasculitis e.g GPA which affects the vasa nervorum supplying individual peripheral nerves causing wide spread nerve damage