Morphine & Pethidine (Meperidine)

Question 1

Morphine main mechanism ??

Answer 1

Pain transmission is inhibited

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Question 2

Pain associated neurotransmitters ??

Answer 2

1. Substance P
2. Acetylcholine
3. Nor epinephrine
4. Serotonin
5. Glutamate

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Question 2

Morphine another mechanism ??

Answer 2

1. Ophoid receptorninn post synaptic nerve terminal
2. Ophoid receptor - MEU
3. Open K channel
4. Inc k efflux
5. K conductance
6. Hyperpolarization
7. Inhibitory post synaptic potential - IPSP

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Question 2

Ophoid receptor type ??

Answer 2

G protein couple receptor

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Question 3

Moprhine mechanism in your own word ?

Answer 3

1. Morphine binds with ophoid receptors in presynaptic nerve terminal
2. Ophoid receptors - MICRO - DELTA - KAPPA
3. Closure of Ca channel
4. Dec Ca influx
5. Decx relese of neurotransmitter

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Question 4

Indications of morphine ??

Answer 4

1. Acute MI
2. Severe somatic pain
3. Chronic pain in terminal cancer patient
4. Obstetric labor
5. Acute pulmonary edema
6. Shivering
7. Cough suppression
8. Non infective diarrhea

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Question 5

Effect of Morphine in MI ??

Answer 5

1. Adequate analgesia
2. Lower adrenergic drive
3. Reduce pulmonary vascular resistance ‘
4. Reduce systemic vascular resistance
5. Reduce susceptibility to ventricular arrythmia

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Question 5

CNS Adverse/ effect of mrophine ?

Answer 5

1. Delirium
2. Sedation
3. Myoclonus
4. Seizures

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DM S S

Question 6

Morphine effect in Acute Pulmonary Edema ???

Answer 6

1. Reduced anxiety
2. Reduced Cardiac preload
3. Reduced afterload

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Question 6

Ophoid like anti-Diarrheal drug ??

Answer 6

1. Loperamide
2. Codeine
3. Diphenoxylate

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Question 7

GI A/E of morphine ??

Answer 7

1. Constipation
2. Urinary retention

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Question 8

Respiratory A/E of morphine ??

Answer 8

1. Respiratory depression
2. Nausea / Vomiting

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Question 9

In head injury manifestation of morphine ??

Answer 9

Inc Intracranial Pressure

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Question 10

contraindications of morphine ?

Answer 10

1. head injury
2. 🤰
3. impaired -pulmonary-renal - endocrine function
4. undiagonised acute visceral pain
5. combining a pure agonist with a weak partial agonist pentazocine

Question 10

why pethidine/meperidine»_space;> morphine ?

Answer 10

1. it does not delay labour like morphine
2. less cardio respiratory depression in fetus

Question 11

functional classfication of morphine ?

pure agonist name ?

Answer 11

1. morphine
2. fenatyl
3. heroine
4. oxy & hydro codeine

Question 12

partial agonists name ?

Answer 12

1. buprenorphine

Question 13

antagonists name ?

Answer 13

1. naloxone
2. naltrexone
3. nalmefene

Question 14

moderate agonists name ?

Answer 14

codeine

Question 15

according to origin ?

natural ophoid ?

Answer 15

morphine
codeine

Question 16

semisynthetic ophoid ?

Answer 16

buprenorphone
oxt & dihydrocodeine

Question 17

synthetic ophoid ?

Answer 17

pethidine
fenatyl
meperidine
nalbupine
afenatyl
su-fenatyl
remi-fenatyl

Question 18

CNS effects of morphine >?

selective depression of CNS ?

Answer 18

1. Analgesia
2. sedation
3. sleep
4. respirstory depression
5. cough suppression
6. hyperthermia

Question 19

selective stimulation of CNS by morphine ?

Answer 19

1. vomiting
2. miosis
3. convulsions
4. hyperactive spinal cord reflexs

Question 20

other CNS effect of Morphine >

Answer 20

dependence changes in mood euphoria dysphoria

Question 21

PNS effect of morphine ?

Answer 21

analgesia

Question 22

other peripheral effects of morphine?

Answer 22

1. CVS-bradycardia + hypotension 2. GIT - constipation 3. renal - urinary retention , dec RBF , anti-diuretics effect 4. uterus - prolong labour 5. neuroendocine - inc release of ADH

Question 23

which ophoid in obstetric labour /

Answer 23

meperidine

Question 24

antitussive drugs ?

Answer 24

1. dextromethorphan 2. codeine

Question 25

which ophoid in shivering ?

Answer 25

1. pethidine

Question 26

endogenous ophoid peptides name ?

Answer 26

1. endorphins 2. dynorphins- A+ B 3. enkephalin

Question 27

Analgesic drugs name /

Answer 27

1. opioid/narcotic 2. non-o/non-n - NSAID

Question 28

What is analgesic drug /

Answer 28

an analgesic is defined as a drug that relieves pain

Question 29

why morphine is restricted drug ?

Answer 29

cause - addiction

Question 30

why contraindicated in impaired respiratory function ?

Answer 30

may cause acute respiratory failure

Question 31

analgesic dose of morphine /

Answer 31

10mg

Question 32

analgesic dose of meperidine

Answer 32

100mg

Question 33

which drugs used as regular analgesic in post operative period ?

Answer 33

1. ketorolac 2. diclofenac 3. naproxane

Question 34

morphine vs pethidine ? | basic 4 ta kotha

Answer 34

1. M= natural 2. late action 3. long duration 4. more potent | pethidine - opposite

Question 35

M VS P? | A/E Diye

Answer 35

1. hypnotic effect 2. respiratory depression 3. cough suppression 4. constipation 5. urinary retensuion

Question 36

histamine realeas by which one ?

Answer 36

morphine = bradycardia + hypotension

Question 37

how to tx a morphine addict ?

Answer 37

1. long term substitutes - methadone + buprenorphine _ heroin 2. b;locking response - naltrexone 3. reducing continued drug use/reducing craving ? - baclofen + ibogaine

Question 38

opioids in which pain type ?

Answer 38

viseral

Question 39

NSAID > pain type ?

Answer 39

somatic

Question 40

which opoids A/E used as indication ?

Answer 40

Diphenoxylate - Constipation anti-emetic drugs 8.51PM 13.4.2025