MSK

Question 1

Uworld: Muscle Structure and Physiology
What is the function of the T-tubule?

Answer 1

Allow depolarization in a uniform manner, allowing synchronized contraction of myofibrils.

Question 2

Pathology: Bone Tumor
Describe Osteosarcoma:

Answer 2

• primary bone tumor in children and young adults
• arise in the metaphases on long bones (eg, proximal tibia, distal femur), where bone proliferation is the highest
• causes Periosteal elevation (ei Codman triangle) and a sunburst periosteal reaction

Question 3

Pathology: Bone Tumor
What cells does osteosarcoma rise from?

Answer 3

Mesenchymal stem cells or osteoblastic progenitor cells

Question 4

Bootcamp: Pharmacology
What is the MOA of Pembrolizumab?

Answer 4

Inhibits PD-1 to improve T lymphocyte immune response