Multisystem

Question 1

Describe the amyloid type: AL

Answer 1

• derived from immunoglobulin light chains eg, Bence Jones protein in the blood or urine
• associated with Multiple myeloma

Question 2

Describe the amyloid type: AA

Answer 2

Associated with chronic inflammation eg, RA, TB

Question 3

Describe the amyloid type: A-beta

Answer 3

Main constituent of amyloid plaques in Alzheimer disease

Question 4

Describe the amyloid type: ATTR

Answer 4

Found in familial amyloid polyneuropathy (caused by a genetic mutation) and senile cardiac amyloidosis (caused by wild-type ATTR accumulation)

Question 5

Describe the amyloid type: A-beta2-M

Answer 5

Derived from beta2-microglobulin, associated with long-term hemodialysis

Question 6

Describe the amyloid type: IAPP (amylin)

Answer 6

Found in T2DM

Question 7

Describe the amyloid type: PrP

Answer 7

Misfolded prion protein found in Creutzfeldt-Jacob disease