NAFLD

Question 1

⚡⚡ MOST COMMON CAUSE of CRYPTOGENIC CIRRHOSIS

🧠⚡Presents with CIRRHOSIS for 1st Time, no other cause for explaination ⚡

Answer 1

NASH / NAFLD

Question 2

NAFLD is ASSOCIATED with

Answer 2

1. Obesity
2. Metabolic Syndrome
3. HAIR-AN Syndrome
4. Insulin Resistance

Question 3

⚡⚡ MOST COMMON METABOLIC DISORDER IN WORLD

Answer 3

NAFLD / NASH

Question 4

⚡⚡ MOST COMMON CHRONIC LIVER DISEASE IN WEST

Answer 4

NAFLD / NASH

Question 5

⚡⚡ MOST COMMON CAUSE of ASYMPTOMATIC LFT Derangement in OPD

Answer 5

NASH

Question 6

Severity of NAFLD / NASH is directly proportional to

Answer 6

Level of Hedgehog pathway

Question 7

Biopsy scoring system in NASH

Answer 7

NAS (NAFLD Activity Score)

Question 8

NAS (NAFLD Activity Score)
Components
🧠⚡SBI ⚡

Answer 8

1. Steatosis (0-3)
2. Ballooning degeneration (0-2)
3. Inflammation Lobular (0-3)

Question 9

NAS (NAFLD Activity Score)
Score

Answer 9

0-2: No NASH
3-4: Probably NASH
≥ 5: NASH

Question 10

Scoring system used for NASH

Answer 10

1. ALT AST Ratio
2. FIB4 Score
3. BARD Score
4. AST Platelet Ratio Index (APRI)
5. NAFLD Fibrosis Score

Question 11

BARD Score

Answer 11

BMI 1
AST ALT Ratio 2
DM type 2 1

Question 12

💊💉 MANAGEMENT of NAFLD

Answer 12

1. Weight Loss (Not Rapid)
   ✨ Drugs
   🎯 Orlistat
   🎯 Phentermine ➕ Topiramate
   🎯 Buprenorphine ➕ Naltrexone
   ✨ Bariatric Surgery
2. Metformin, Pioglitazone, Pentoxyfylline
3. Exercise: 10,000 steps/day (OR) 200 min/wk of Moderate Exercise

Question 13

Rapid Weight Loss is ASSOCIATED with

Answer 13

Steatosis