obesity

Question 1

where is leptin secretd

Answer 1

white adipose tissue in proportion to fat mass

Question 2

role of leptin

Answer 2

it acts on the hypothalamus to inhibit hunger and promote energy expenditure.

Question 3

where is ghrelin secreted

Answer 3

gastric fundus

Question 4

role of ghrelin

Answer 4

stimulate appetite by acting on the hypothalamus.

Question 5

in obesity how do levels of ghrelin and leptin change?

Answer 5

ghrelin = decrease
leptin = increase - but resistant to, so remain hungry

Question 6

what is the role of NPY

Answer 6

appetite stimulator - preference for calorie dense foods
low levels of leptin trigger NPY release

Question 7

where is somatostatin released and its role

Answer 7

released by delta cells of pancreas
- mostly inhibitory functions

Question 8

explain the nf loop of glucagon secretion

Answer 8

glucagon is secreted in response to hypoglycaemia, it moves hepatic glucose stores through glycogenolysis and stimulates gluconeogenesis.
glucagon stimulates somatostatin release from pancreatic delta cells to inhibit further glucagon release to prevent hyperglycaemia