P16 - Platelets

Question 1

platelet production in

Answer 1

• marrow

Question 2

typical amount of platelets

Answer 2

• 1/10 to 30 RBCs

Question 3

giant platelets are common finding in

Answer 3

• healthy cats

Question 4

giant platelets diameter

Answer 4

• larger than erythrocyte diameter

Question 5

thrombocytopenia

Answer 5

• platelet concentration is lower than reference interval

Question 6

major pathogenesis of thrombocytopenia (6)

Answer 6

• pseudothrombocytopenia
• decreased production
• decreased survival
• hemodilution
• abnormal distribution (sequestration)
• idiopathic or multifactorial

Question 7

pathogenesis of immune-mediated thrombocytopenia

Answer 7

• formation of anti-platelet antibodies

- antibodies bind to platelets -> macrophages engulf

Question 8

pathogenesis of consumptive thrombocytopenia

Answer 8

• damage to endothelium or activation of coagulation cascade -> activation of platelets
• aggregation and recruitment of platelets -> removed from blood

Question 9

pathogenesis of infectious canine cyclin thrombocytopenia

Answer 9

• immune-mediated destruction or sequestration

Question 10

thrombocytosis

Answer 10

• platelet concentration > reference interval

Question 11

pathogenesis of thromocytosis (3)

Answer 11

• increase production (inflammatory Fe deficiency)
• clonal (neoplasia)
• redistribution (exercise excitement)

Question 12

pseudothrombocytopenia caused by

Answer 12

• platelet clumps

- giant platelets

Question 13

species with lower platelet concentration

Answer 13

• horses

Question 14

impedance method

Answer 14

• leas to pseudothrombocytopenia in cats because their platelet are large

Question 15

giant platelets due to genetic variations in

Answer 15

• cavalier king charles spaniels