P3 PATHOLOGY

Question 1

Systemic chronic inflammatory connective tissue autoimmune disease

Answer 1

Rheumatoid arthritis

Question 2

particular gene that can cause RA

Answer 2

HLA-DR4 from class 2 MHC

Question 3

Specific antibodies are detected against

Answer 3

Fc portion of IgG

Question 4

mention at least 3 diseases where RF is detected

Answer 4

• SLE
• Lyme disease
• sjorgen syndrome
• cirrhosis
• pulmonary fibrosis

Question 5

Exudation of fibrin in joint space will cause what and described as what

Answer 5

• causes fibrin nodules
  -described as rice bodies

Question 6

synovial hypertrophy Manifested as

Answer 6

Exuberant papillary foldings of synovium

Question 7

Lymphocytes that are mostly seen in the infiltrate

Answer 7

CD4 T cells

Question 8

Outgrowth of synovium over the surface of articular cartilage

Answer 8

pannus

Question 9

pannus product that enables the erosion of pannus

Answer 9

Collagenase

Question 10

chemicals produced by pannus stimulates osteoporosis

Answer 10

cytokines ; IL-1 , IL-2 , TNF-ALPHA , PGE2

Question 11

mention some pannus effects on joints

Answer 11

• joint narrowing
  Deformities
  joint destruction
  fibrous ankylosis
• bony ankylosis

Question 12

Identify 1 , 2 & 3

Answer 12

1- numerous hypertrophic papillary projections
2- focal pale fibirin depositions
3- brownish : hemosiderin accumulation

Question 13

Identify 4,5& 6

Answer 13

4- synovial hypertophy
5- hyperplasia
6- prominent lymphoid follicles

Question 14

Identify what is seen

Answer 14

Rheumatoid nodule ,, subcutaneous mass

Question 15

identify what is shown
what is your diagnosis

Answer 15

Central area of necrosis surrounded by macrophages & chronic inflammatory infiltrate

Question 16

Mention at least 4 extra-articular manifestations

Answer 16

• rheumatoid nodules
• vasculitis
• cardiac disease
• amyloidosis
• serosal inflammation
• pulmonary disease
  -anaemia
• eye involvement
• felty’s syndrome