Pharm equations

Question 1

Low Vd

Answer 1

Blood; large/charged and/or protein-bound molecules

Question 2

Maintenance dose =

Answer 2

C_p x CL x dose interval/F

Question 3

Loading dose =

Answer 3

C_P x Vd/F

Question 4

CL =

Answer 4

Rate of elimination/plasma concentration

Question 5

High Vd

Answer 5

All tissues including fat; small lipophilic molecules, especially if bound to tissue protein

Question 6

T_1/2=

Answer 6

0.693xVd/CL

Question 7

Vd=

Answer 7

amount of drug in the body/amount of blood in the plasma

Question 8

Medium Vd

Answer 8

ECF, small hydrophilic molecules