Pharmaceutical Inserts

Question 1

• Solid or semi-solid masses intended to be inserted into a body orifice
• Can give local or systemic effects

Answer 1

Pharmaceutical Inserts

Question 2

_______________

• Melt in body temperature
• Dissolve in secretions of the body

Disadvantage:
* Inconvenient
* Erratic absorption

Answer 2

Suppositories

Question 3

Types of Suppositories

1. ____________
   * Cylindrical with tapered ends
   * 32mm(1.5 inches)long
   * to promote defecation or treat anorectal diseases

Local Effects:
* ________
* Relieving pain/inflammation from hemorrhoids

Systemic Effects:
* ________
* ________

Advantages:
* Low cost
* No technical difficulties upon administration
* Partially avoid first-pass effect

Disadvantages:
* Surface area for absorption is small
* Defecation may interrupt absorption
* Less fluid content
* More EXPENSIVE than solid DF
* Stigma of violating patients

Answer 3

Types of Suppositories

1. Rectal

Local Effects:
* Laxation
* Relieving pain/inflammation from hemorrhoids

Systemic Effects:
* Analgesic
* Antiemetic

Question 4

Types of Suppositories

2. _____________ (__________)

• For bacterial/fungal
• Can also be used for HRT
• Buffered to pH ___
• Usually GLOBULAR in form

Answer 4

2. Vaginal (Pessaries)

• pH 4.5

Question 5

Types of Suppositories

3. __________ (__________)

• Inserted into urethra after urinating
• Pencil-shaped suppositories
• 3-6 mm diameter
• 140 mm long

Answer 5

3. Urethral (Bougies)

Question 6

B. ______________

Criteria:
* Inert, non-irritating, and non-sensitizing
* Film does not melt in RT
* Dissolves rapidly in the cavity fluid

Answer 6

B. Suppository Bases

Question 7

B. Suppository Bases

1. __________ Bases
   a. __________
   b. __________
   c. __________
2. _________/_________ Base
   a. __________
   b. __________

Answer 7

B. Suppository Bases

1. Oleaginous Bases
   a. Cocoa Butter
   b. Wecobee
   c. Witepsol
2. Water-Soluble/Miscible Base
   a. Glycerinated Gelatin
   b. Polyethylene Glycol

Question 8

C. _____________

• Ovoid or bullet-shaped tablets
• Uses a plastic inserter for local effects
• Contains microbial agents

Answer 8

C. Vaginal Tablets/Inserts

Question 9

D. ______________

• Long-acting
• Provides continuous release of drug
• Administered parenterally/subcutaneously

Answer 9

D. Implants/Pellets