pharmacogenetics Flashcards by Sherbina Pakirathan

Q

various types of polymorphism

A

SNPS

Functional

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Q

pharmacogenomics ——>

A

drug metabolism

drug target

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Q

what is under drug metabolism

A

CYP206

NAT2

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Q

what is under drug target

A

ALOX 5

EGFR

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Q

what is under CYP206

A

lack of codeine

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Q

what is under NAT2

A

autoimmune

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Q

what is under ALOX5

A

lack of 5-lipoxygenase inhibit response

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Q

what is under EGFR

A

tumour reg. response

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Q

S warfarin is catalysed by

A

CIYP2C9

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Q

R warfarin is catalysed by

A

CYPIA2

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Q

2 common warfarin metabolism genetic variation

A

CYP2CP (ARG and ILE)

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Q

codeine is made into

A

prodrug

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Q

codeine is …… into morphine for activity

A

metabolised

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Q

prodrug need ………… to work

A

metabolism

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Q

active drug …………. by metabolism

A

inactive

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