when does the neural tube develop and what does it become?
3-4 weeks, becomes brain and spinal cord
what occurs during the embryonic stage?
organs form
when do reflex-like reactions such as swallowing appear?
around 10 weeks
when might mother first feel baby moving?
around week 13 - kicking may be felt around week 14
when is a fetus viable outside the womb with medical attention?
around week 28
what is considered premature birth?
birth before 38 weeks
which senses develop in the womb?
movement, taste, smell, hearing, vison and learning
how do fetuses move in the womb?
active rubbing / touching face and umbilical cord, explore surroundings with hands
what behaviour predicts handedness after birth?
thumb-sucking
how do fetuses respond to sound?
heart rate changes to parental voice - can recognise and remember sounds
name key studies on prenatal hearing and learning
Voegtline et al 2013, Kisilevsky et al 2003, Webb et al 2015, DeCasper & Spence 1986
what are teratogens?
factors causing defects, disruptions or deformations in fetal development
examples of teratogens
drugs (opioids, cigarettes, alcohol), maternal health (nutrition, stress), environmental factors (pollution), diseases (zika, covid), specific compounds (lead, radiation, thalidomide), new issues like mircoplastics
what are the main principles of teratogen impact?
dose-response relationship, fetal programming, and critical / sensitive periods
what defects did thalidomide cause?
limb disruption, brain / internal organ damage, chronic pain, poor mental / emotional health in adults
when is thalidomide most dangerous?
4th-6th week after conception
what developmental principle does thalidomide illustrate?
critical and sensitive periods
what did project ice storm study?
objective and subjective measures of stress during pregnancy
when is stress most impactful on fetal development?
mid to late pregnancy
what outcomes can maternal stress affect?
temperament, cognitive outcomes, and fetal programming via HPA axis changes
what is fetal programming?
experiences in womb (nutrition, stress, illness) guide development, with effects potentially appearing later in life
how does pollution affect prenatal development?
causes premature birth, intrauterine (within uterus) growth restriction via placenta damage, hormonal disruption, inflammation and oxidative stress
what is a dose-response relationship in teratogen exposure?
higher exposure increases risk and severity of damage
example of a successful intervention to reduce pollution-related fetal harm
Japan’s 1992 emission control law : reduced NOx and SO2 - 10% decrease in fetal death rate