primary biliary cirrhosis

Question 1

what is 1ry biliary cirrhosis

Answer 1

condition where immune system attacks small bile ducts within live r

Question 2

what happens

Answer 2

obstruction of outflow of bile (cholestasis)

back pressure of bile obstruction ultimately leads to fibrosis, scarring and liver failure

Question 3

presentation

Answer 3

fatigue
pruritus 
GI disturbance
jaundice
pale stools 
xanthoma 
xanthelasma 
signs of cirrhosis

Question 4

associations

Answer 4

middle aged women
other autoimmune conditions
rheumatoid conditins

Question 5

diagnosis

Answer 5

LFTs
autoantibodies
liver biopsy

Question 6

LFT findings

Answer 6

alkaline phosophhatase is first enzyme to be raised

other enzymes and bilirubin in later disease

Question 7

autoantibodies

Answer 7

anti-mitochondrial antibodies

anti-nuclear antibodies

Question 8

treatment

Answer 8

ursodeoxycholic acid - reduce cholesterol absioprtion

colestyramine

Question 9

important end results of disease

Answer 9

advanced liver cirrhosis

portal hypertension