Progeria

Question 1

What is progeria ?

How common is it ?

Answer 1

• Premature aging
• Extremely rare

Question 2

What causes progeria ?

Answer 2

Caused by novel mutation in the Lamin A defect (LMNA)
unstable nuclear envelope, leading to premature cell death. LMNA mutations also involved in muscular dystrophy

Question 3

What are symptoms of progeria ?

Answer 3

MSK defects associated with aging
Lack of muscle mass, strength, tone and power
Hip dislocation