1
Q
Anticholinergic SE (Dryness, confusion)
A
“PANDAH on a TRIcycle”
- Promethazine
- Atropine
- Neuroleptics (low potency)
- Digoxin
- Amantadine
- H1 blockers
- TCAs
2
Q
Coronary Vasospasm
A
“META takes Cocaine”
- Methamphetamines
- Ergotamines
- Triptans
- Amphetamines
- Cocaine
3
Q
Cutaneous Flushing
A
VAND
- Vancomycin
- Adenosine
- Niacine
- Dihydropyridine CCBs
4
Q
Dilated Cardiomyopathy
A
- Doxorubicin
- Daunorubicin
5
Q
Torsades de pointes
Rx?
A
13 CHaMP
- Class IA sodium channel blockers
- Class III potassium channel blockers
- Chloroquine
- Haloperidol
- Macrolides
- Protease Inhibitors
Rx for torsades: Push IV Magnesium
6
Q
Agranulocytosis
A
3Cs, 2 thyroid drugs, Dap
- Clozapine
- Carbamaepine
- Colchicine
- PTU
- Methimazole
- Dapsone
7
Q
Aplastic Anemia
A
CB MN for PTU
- Chloramphenicol (gray baby)
- Benzene
- Methimazole
- NSAIDs
- PTU
8
Q
Gray Baby Syndrome
A
Chloramphenicol
9
Q
Hemolysis in G6PD-deficient patients
A
“eat Favas in PIINDANS country (red soiled area of Australia)”
- Fava beans
- Primaquine
- Isoniazid, Ibuprofen
- Naphthalene
- Dapsone
- high-dose Aspirin
- Nitrofurantoin (UTIs)
- Sulfonamides
10
Q
Megaloblastic anemia
A
PMS no Zs
- Phenytoin,
- Methotrexate
- Sulfa drugs
- Zidovudine
11
Q
Thrombocytopenia
A
- Heparin (HIT)
- H2 blockers (cimetidine)
12
Q
Thrombosis
A
OCPs (especially if smoker >35 years old)
13
Q
Pulmonary fibrosis
A
- Bleomycin
- Busulfan
- Amiodarone (LFTs)
14
Q
Acute cholestatic hepatitis
A
Erythromycin estolate (don’t give to patients with liver disease!)
15
Q
Focal to massive hepatic necrosis
A
Kill your liver, HAVe A mushroom!
- Halothane
- Acetaminophen
- Valproic acid
- Amanita phalloides (mushroom toxin)
16
Q
Hepatitis
A
Isoniazid (INH)
17
Q
Pseudomembranous Colitis
A
- Any antibiotic but notoriously:
- Clindamycin
- Ampicillin
18
Q
Adrenocortical insufficiency
A
Withdrawal of Corticosteroids
19
Q
Gynecomastia
A
*Booby’s got SMACKED! *
- Spironolactone
- Marijuana
- chronic Alcohol use
- Cimetidine
- Ketoconazole
- Estrogens
- Digitalis
20
Q
Hot Flashes
A
- Tamoxifen
- Clomiphene
21
Q
Hypothyroidism
A
- Amiodarone (TFTs),
- Lithium
- Sulfonamides
22
Q
Hyperglycemia
A
- Niacin
- Tacrolimus
- Protease inhibitors
23
Q
Fat redistribution
A
- Steroids
- Protease inhibitors
- HIV breaks down fat and causes sunken in facial features (temporal wasting),
- Insulin injections
24
Q
Gingival hyperplasia
A
- Phenytoin
- Verapamil
25
Gout
Diuresis:
*Diuretics and Nic cycles up pyramid with gou*t
* Furosemide
* Thiazides
* Niacin
* Cyclosporin
* Pyrazinamide
26
Myopathies
*PSyCHING* myopathies will elevate CPK
* **P**enicillamine
* **S**tatins
* **C**olchicine
* **H**ydroxychloroquine
* **I**NF-alpha
* **N**iacin
* **G**lucocorticoids
27
$ Osteoporosis
* Corticosteroids (if on for 3 months, get on bisphosphonate)
* Heparin
28
Photosensitivity
* **S**ulfonamides
* **A**miodarone
* **T**etracycline
29
Steven-Johnson Syndrome
Seizure drugs, Cillins and Sulfas:
* Seizure meds: Ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital.
* Penicillin
* Sulfas
* Allopurinol
30
Drug-induced SLE
"SHIPP"
* Sulfonamides
* Hydralazine
* INH
* Procainamide
* Phenytoin
31
Tendon rupture/cartilage damage
Fluoroquinolones
32
Nephrogenic DI
Rx for nephrogenic DI?
* Lithium
* Demeclocycline
Rx for DI - HCTZ, indomethacin, amiloride (add to lithium induced)
33
Fanconi syndrome - proximal tubular defect
* Expired tetracycline
* Heavy metal exposure
* Wilson disease
34
Interstitial Nephritis
* Methicillin
* NSAIDS
* Furosemide
35
Hemorrhagic Cystitis
* Cyclophosphamide
* Ifosfamide (MESNA can prevent urotoxic metabolite from injuring the bladder)
36
SIADH
* Carbamazepine
* Cyclophosphamide
37
Cinchonism (Dizziness + headache + vision changes + tinnitus)
* Quinidine (Class IA)
* Quinine
38
Reversible drug-induced parkinsons
* Reserpine
* Antipsychotics (haloperidol)
* Metoclopramide
* MTPT
39
Seizures
*"I IBM WEPT from a seizure"*
* **I**soniazid, **I**mipenem/cilastatin
* **B**uproprion
* **M**etoclopramide
* **W**ithdrawal: Benzos or Alcohol
* **E**nflurane
* evening **P**rimrose oil
* **T**ramadol
40
Tardive Dyskinesia
High Potency antipsychotics (Fluphenazine, Haloperidol)
41
Disulfiram-like reaction
*"Drink Corona at Midnight and Suffer Post Binge"*
* **D**isulfiram
* Certain **C**ephalosporins,
* **M**etronidazole
* First-generation **S**ulfonylureas
* **P**rocarbazine (Anti-cancer alkylating agent)
42
Nephrotoxic + Ototoxicity
Loop VAC
* **Loop** diuretics
* **V**ancomycin
* **A**minoglycosides
* **C**isplatin
43
Acetaminophen
**N-acetylcystine (relenishes glutathione)**
Toxic dose - 12g in 24 hours
Max recommended dose - 4g in 24 hours
44
Salicylates
Sodium Bicarbonate (alkalinize urine), dialysis
45
Amphetamines
NH4Cl (acidify urine)
(ammonium chloride)
Amphetamines are basic
46
Acetylcholinesterase inhibitors, organophosphates
Atropine, pralidoxime - regenerates acetylcholinesterase
47
Antimuscarinic, anticholinergic agents
Physostigmine salicylate
48
Beta blockers
Glucagon, Calcium, Atropine
49
Digitalis
Stop dig; Atropine
KLAM - Potassium, Lidocaine, Anti-dig Fab fragments, magnesium
50
Iron
Deferoxamine
51
Lead
CaEDTA, dimercaprol, succimer, penicillamine
52
Mercury, arsenic, gold
Dimercaprol (BAL), succimer
53
Copper, arsenic, gold
Penicillamine
54
Cyanide, from house fire or sodium nitroprusside OD
Nitrie, hydroxocobalamin, thiosulfate
55
Methemoglobin
Methylene blue, vitamin C
56
Carbon monoxide
100% O2, hyperbaric O2
57
Methanol
Fomepizole \> ethanol, dialysis
58
Ethylene glycol (antifreeze)
Fomepizole \> ethanol, dialysis
59
Opioids
Naloxone/naltrexone
Often baby is OD due to mother receiving opioids for pain management in pregnancy
60
Benzodiazepines
Flumazenil
61
TCAs
Sodium bicarbonate (plasma alkalinization)
62
Heparin
Protamine
63
Warfarin
Vitamin K, fres frozn plasma
(Takes 3-5 days for clotting factos to come back online)
64
PA, streptokinase, urokinase
Aminocaproic acid
65
Theophylline
(Tacycardia)
Beta-blocker
DIT Phase II Chapters
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