Schizophrenia Flashcards

(51 cards)

1
Q

What is schizophrenia?

A

A psychotic disorder where people loose their sense of self and reality.

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2
Q

What is the ICD

A

A manual listing hundreds of mental disorders with their associated symptoms used by medical professionals to diagnose mental health problems.

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3
Q

What are the positive symptoms of schizophrenia?

A
  • hallucinations (unusual SENSORY experiences).
  • delusions (firm, illogical BELIEFS)
  • disorganised speech/ thought disorders (incoherent, rambling, jumping topics, making little sense).
  • catatonic behaviours (extreme physical behaviour such as stillness, rigidity, excitement or repetitive movements)
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4
Q

What are the negative symptoms of schizophrenia?

A
  • Avolation
  • Alogia
  • Anhedonia
    -Asociality
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5
Q

What is avolition?

A

complete lack of motivation to complete purposeful tasks or engage in daily activities.
Such as personal hygiene/ work.

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6
Q

What is alogia?

A

Reduction in quantity and quality of speech, resulting in slow/ simple/ vague responses.

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7
Q

Anhedonia?

A

Reduced ability to experience pleasure, resulting in reduced emotional expression.
Not smiling/ using facial expressions.

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8
Q

Asociality?

A

A tendency to avoid social interaction, preferring to spend time alone.

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9
Q

What is the prevalence of schizophrenia?

A

Around 1% of the British population is diagnosed with schizophrenia. (Over 600k people in the UK).

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10
Q

What is a statistic about schizophrenia around age and sex? (Age, prevalence, recovery, gender, ethnicity)

A

Age- adult onset disorder, normally diagnosed before the age of 40
Prevalence- 1% of the population are diagnosed with schizophrenia
Recovery- 10 years after diagnosis: 25% full recovery, 25% much improved, 25% need support, 15% hospitalised and 10% dead
Sex- equal in women and men, usually woman in 30s and men in 20s
Ethnicity- Caribbean and African heritage more likely to be diagnosed than white. Asian heritage lower average rates.

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11
Q

How much more likely are working class people to suffer from schizophrenia than higher social groups?

A

About 5x more likely

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12
Q

Do people who develop schizophrenia in the middle class or upper class tend to stay in the social class they were born into?

A

No, they often have moved to a lower class by the time they contact psychiatric services.

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13
Q

Why might individuals with mental health problems face financial challenges?

A
  • difficulty finding employment due to workplace discrimintaion
  • costs of treatment
  • also needing to pay for basic family needs
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14
Q

Describe the social drift theory of schizophrenia.

A
  • people with schizophrenia get caught in a cycle which leads to a downward spiral into poverty and loss of status
  • the cycle involves DISENGAGEMNENT of individuals who don’t feel a part of society, possibly due to their symptoms that they’re suffering from.
  • They begin to drop out and stop following societal norms which results in them facing rejection from society
  • Rejection by society leads to further disengagement, which results in further disengagement and so on…
  • It’s very difficult to recover from being at the bottom of society, and when they also have schizophrenia it’s hard for them to get better.
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15
Q

SDT criticism 1: problems establishing cause and effect.

A
  • an alternative theory (social causation theory) suggests that being in a lower class drives people to develop schizophrenia, rather than the other way round.
  • Living at the bottom of society involves factors (e.g. poverty, deprived area, more discrimination) which could lead to stressors that trigger schizophrenia.
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16
Q

SDT criticism 2: physical factors associated with low social classes may be the cause of schizophrenia.

A
  • low social classes may experience more poverty and children may have poor diet and nutrition can increase chances of developing schizophrenia
  • complications in pregnancy and birth can increase a child’s chances of developing schizophrenia.
  • more likely to be issues for lower class families which explains why people with schizophrenia are found more in this class.
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17
Q

SDT criticism 2: bias in diagnosis.

A
  • psychiatrists are more likely to diagnose people from lower social classes with schizophrenia
  • they might assume that lower class is more prone to everyday stresses but the rich may just be seen as eccentric
  • psychologists are often from higher classes so less likely to relate and understand working class problems
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18
Q

SDT criticism 4: too much focus on the role of society.

A
  • family conflict and stress can contribute to disorder as linked by evidence
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19
Q

SDT criticism 5: ignores biological factors.

A
  • evidence suggest that the disorder starts with genes that affect the way the brain works.
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20
Q

What is the role of dopamine and what happens if theres too much?

A
  • dopamine is a neurotransmitter responsible for attention, mood, movement and perception.
  • it affects the way the brain functions
  • Too much dopamine means too many messages being fired around and movements can become erratic, people may experience hallucinations and delusions.
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21
Q

What happens to the dopaminergic neurones that transmit dopamine of people with schizophrenia and what does it result in?

A
  • fire too much or too easily
  • can lead to the positive symptoms of schizophrenia
22
Q

What does having high numbers of dopamine (D2) receptors on certain neurones result in with people with schizophrenia?

A
  • more dopamine binds to those receptors
  • therefore more triggers neurones firing across synapses more frequently
  • results in positive symptoms of schizophrenia
23
Q

What do test show about the brain activity of people with schizophrenia?

A
  • blood flow is lower in the frontal cortex region of the brain
  • that area is less frequently activated when certain tasks are carried out.
  • also smaller in volume and less grey matter -> neurons less densely packed
24
Q

What is the prefrontal cortex and how is it like in people with schizophrenia?

A

-the control centre of the brain
- less frequently activated during takes and restricted blood flow
- why people lose control of psychological functioning and struggle to be organised. (Negative symptoms)

25
What is the temporal lobe and what is it like in people with schizophrenia?
- processing auditory information and interpreting visual stimuli - lower in volume mainly due to lack of grey matter. - may explain the hallucinations
26
What is the hippocampus and what is it like in people with schizophrenia?
- role in forming memories and emotions - smaller in volume - more severe the disorder-> more deflated hippocampus
27
Does the neurological damage in schizophrenia always occur in adulthood?
- researchers argue that some neurological damage may have occurred before they are born - brain might’ve ben exposed to an infection whilst still developing in the wound.
28
BTS criticism 1: focuses too much on nature
- the evidence of the brains of people with schizophrenia working differently is not enough to cause the disorder by itself. - the brain still needs to be interacting with what’s happening in the environment to produce symptoms such as hallucinations
29
BTS criticism 1: brain disfunction could be an effect, not the cause
- evidence comes from scans after diagnosis so researchers can’t be sure what came first. - brain function and structure may change after something else triggered the disorder
30
BTS criticism 2: too deterministic
- schizophrenia may not be completely caused by brain function and structure. - the theory suggest that people with schizophrenia can’t control their disorder and have no free will over trying to mentally control their symptoms which is pessimistic
31
BTS criticism 3: too reductionist
- too simplistic to try to explain such a complex disorder by just looking at the brain and one neurochemical - a number of different factors may be working together to cause schizophrenia rather than just one factor.
32
Background of Daniel et al?
- several studies have shown low levels of activity in the prefrontal cortexes of people with schizophrenia. - low levels of activity linked to dopamine activity in the brain. - studies have shown that dopamine is important in suppressing random activity in the brain and helps focus on specific stimuli
33
Hypotheses of Daniel et al?
- a dopamine agonist will increase activity in the prefrontal cortex during a cognitive task
34
What is an agonist? What type of agonist did the researchers use in Daniel et al study?
- a substance that stimulated dopamine activity in the brain - used amphetamine which is a chemical that increases alertness and energy and improves mood
35
What did the researchers use to scan the participants brain activity during the cognitive task?
SPECT scan - uses gamma rays to show how blood flows to tissues and organs
36
37
IV and DV in Daniel et al?
IV- whether pps given amphetamine or not DV- performance on the Wisconsin Card Sorting test
38
Sample of Daniel et al study?
- 10 in-patients from National institute of mental health Research Wards in Washington USA.
39
Why was the sample choice ethical?
- study had the approval of the institutional review board - all pps gave informed consent
40
What was the race, sexes and ages of Daniel et al participants?
- mostly white but also black - 1 more male than female - aged 21 to 45
41
What were the criteria that the sample met?
- each patient met criteria for chronic schizophrenia - stabilised for at least six weeks on a fixed dose of haloperidol - clinically stable at the time of study to cooperate with the SPECT and testing procedures - free of any illnesses that could’ve affected blood flow - free of alcohol/ drug use
42
Materials of Daniel et al study?
- SPECT scan capable of recording 80 projections in 5 seconds - semi reclined comfortable chair for pps to be scanned
43
How many scans did each participant undergo and how many days apart?
- two scans - two to four days apart
44
What did each scan involve?
- a mock test to get pps used to set up - a simple sensory motor control test where pps matched bars on a screen based on their orientation - the prefrontal activation test (WCST)
45
What was the BAR task for?
- to show the normal baseline brain activity without complex thinking. It was a control
46
What experimental design did Daniel e al use?
- repeated measures design but used counterbalancing
47
What is counterbalancing?
- experimental technique used to reduce order effects by having half the participants perform the conditions in one order (A then B) and the other half in another order (B then A)
48
Procedure for Daniel et al study?
- 5 pps did BAR test first and the other five did WCST first - on the two test days pps received either amphetamine or placebo in an order that was counterbalanced - BAR and WCST carried out on computers an required similar motor responses
49
Results of Daniel et al study?
- amphetamine significantly increased activity in the prefrontal cortex during the WCST but had no significant effect during the bar task - amphetamine had minimal effect on regional cerebral blood flow during BAR or WCST - Amphetamine had a small but positive affect on the WCST performance. No such affect when placebo was used - Three patients showed significant improvement when treated with amphetamine - 1 patient got significantly worse when treated with amphetamine possibly due to increased dopamine levels worsening positive symptoms
50
Conclusions of Daniel et al study?
- amphetamine significantly increased focus of cortex during cognitive task as expected (despite reducing cerebral blood flow unexpectedly) - results in line with animal studies showing ho dopamine controls and enhances activity in the cortex - suggested that symptoms of schizophrenia are treatable and can be reversed with drug treatment - overall, study supports biological theory as it shows a link between symptoms and brain function
51
Criticisms of Daniel et al?
- small sample, not representative and generalisable to draw conclusions from - sample culturally based (USA and mostly white) even tough theses evidence of different rates of schizophrenia between different ethnic groups - lacked temporal validity (whether findings are valid and relevant over time) used different systems for diagnosing schizophrenia than the one used today - unethical to use scans when we don’t know about the long term consequences of them