Stomach secretion

Question 1

Vagus nerve

Answer 1

ACH to stimulates parietal cells
GRP to stimulates G cells

Therefore atropine does NOT block stimulation of parietal cells.

Question 2

Gastrin does

Answer 2

Increases secretion primarily through its effect on ECL cells
(leading to histamine release) rather than through its effect on parietal cells.

Question 3

Parietal cells

Answer 3

Histamine 2: Increase cAMP leas to activates of ATPase that secretes H+
-this blocked by prostagladin and somatostatin

Gastrin: Gq=> IP3/Ca2+ also activates ATPase

Question 4

Brunner’s gland

Answer 4

Duodenal submucosal:
Secretes alkaline muscus

Hypertrophy seen in peptic ulcer disease.