Gamow
discovered that codons consisted of three bases
Nirenberg & Matthael
took a string a uracils to see what they coded for
confirmed that codons consist of three nucleotides
Start Codon
AUG
methionine
Stop Codons
UAA
UAG
UGA
Open Reading Frame
entire continuous sequence of a gene that begins at a triplet start codon and ends at a triplet stop codon
Reading Frames
reflects the way a nucleotide sequence can be read
-can be read on the first second or third nucleotide
Frameshift Mutations
-nucleotides are added or removed from the sequence