Tranexamic Acid

Question 1

Tranexamic Acid Class

Answer 1

Antifibrinolytic

Question 2

Tranexamic Acid MOA

Answer 2

Inhibitor to the Lysine receptor found on plasminogen, preventing plasmin from binding to and ultimately stabilizing the fibrin matrix

Question 3

Tranexamic Acid Indications

Answer 3

Traumatic injuries within the last three hours with either:
signs and symptoms of hemorrhagic shock with SBP<90
AND/OR
significant hemorrhage with heart rate >/= 120

Question 4

Tranexamic Acid Contraindications (3)

Answer 4

Suspected traumatic brain injury
Pediatrics
Arterial or venous thromboembolism

Question 5

Tranexamic Acid Adult Dose

Answer 5

1g in 50-100mL over 10 minutes IVPB

Question 6

Tranexamic Acid Pregnancy Classification

Answer 6

B (not harmful to animals, untested in humans)

Question 7

Tranexamic Acid Peds Dose

Answer 7

NO