Type II

Question 1

Cytotoxic Reactions

Answer 1

• Autoantibodies directed against self cells tht have foreign protein or other antigen
• Autoantibodies bind w/ self cell creating immune complex
• Self cell destroyed w/ attached protein
• EX
  > hemolytic transfusion reactions; pt receives wrong blood type during tansfusion

Question 2

Cytotoxic Reactions - CMs

Answer 2

• Pallor
• Fatigue
• Lightheadedness
• Weakness
• Dark urine
• Jaundice
• Heart murmur - tachy
• Enlarged liver/spleen

Question 3

Cytotoxic Reactions - Collaborative Management

Answer 3

• Stop offending drug or blood product
• Plasmapheresis
  > filtration of blood to remove antibodies
• Treat symptoms
• Complication
  > hemolytic crisis
  > kidney failure: kidneys working hard to “clean up”

Question 4

Hemolytic Crisis

Answer 4

• Large #s of RBCs are destroyed over short time
• Body can’t make enough RBCs to replace destroyed RBCs
  > severe anemia leads to kidney damage
• Precipitated by nonspecific factors
  > infection, surgery, & transfusion
  > kidney damage occurs due to large deposits of debris & clotting