Vasculitis

Question 1

Arterial wall layer ?

P-65

Answer 1

1. Intima = Endothelial
2. Media = Smooth muscle
3. Adventitia = Connective tissue

Question 2

Inflammation of the blood vessel wall ?

Pathoma-65

Answer 2

Vasculitis

Question 3

Small vessel vasculitis branches ?

P-65

Answer 3

1. Arterioles
2. Capillaries
3. Venules

Question 3

Medium vessel vasculitis branches ?

P-65

Answer 3

Muscular arteries & that supply organs

Question 4

Large vessel vasculitis branches ?

P-65

Answer 4

Aorta & its major branches

Question 5

Clinical features of Vasculitis ??

P-65

Answer 5

1. Fever
2. Fatigue
3. Weight loss
4. Malaise
5. Organ ischemia - thrombosis of the inflammed vessels
6. Healing - Fibrosis

P-65

Question 6

Large vessels vasculitis example ?

2 example

P-65

Answer 6

1. Temporal/Giant cell A - Carotid A
2. Takayasu A - Aortic arch at branch

Question 6

Tx of large vessels vasculitis ?

P-65

Answer 6

Corticosteroids

Question 7

Granulomatous vasculitis that involves branches of the carotid artey ?

p

Answer 7

Temporal / Giant cell arteries vasculitis

Question 7

Age of occurance of large vessels vasculitis ?

p-65

Answer 7

1. Temporal / Giant A = >50yr
2. Takayasu A = <50yr

Question 8

ESR level in large vessels vasculitis ?

Answer 8

Elevated

P=-65

Question 9

Clinical features of temporal / giant artery vasculitis ?

Answer 9

1. Headache - Temporal Artery
2. Visual disturbance - OPthalmic A
3. Jaw claudication
4. Flu like symptoms
5. Muscle & joint pain - Polymyalgia rheumatica

Question 10

Biopsy result of temporal / giant A vasculuitis ?

P-65

Answer 10

-inflammed vessel wall
-with giant cells and intimal fibrosis

Question 11

Pulse less disease ??

p-65

Answer 11

Takayasu arteries

Question 11

Lesions are segmented - thats why biopsy need —-???

P-65

Answer 11

A long segment of vessels ,
(-) biopsy doesnot exclude disease

Question 12

Medium vessels vasculitis examples??

P-65

Answer 12

1. Polyarthritis nodosa
2. Kawasaki disease
3. Buerger disease

Question 13

Polyarteritis nodosa meaning >??

P-65

Answer 13

Necrotizing vasculitis involving multiple organs , lungs are spoared

Question 14

Classical presenattion of polyarteritis’ nodosa ??

P-65

Answer 14

1. HTN - Renal A
2. Ab pain - Mesenteric A
3. Skin lesion
4. Neurologic disturbance

Question 15

Assocition of PN ?

Answer 15

HBsAg

Question 16

Early lesion features of PN >

P-66

Answer 16

Transmural inflammation with fibrinoid necrosis

Question 16

Tx of PN ?

P-66

Answer 16

1. Corticosteroids
2. Cyclophosphamide

Question 17

Healing process of PN ??

P-66

Answer 17

Fibrosis

Question 17

Tx of Kawasaki disease ??

P-66

Answer 17

Aspirine

{{{most exceptional case }}}

Question 18

Imaging show of PN ?

Answer 18

String of pearls appearance

P-66

Question 19

Coronary artery involvement in kawasaki disease ?? | p-66

Answer 19

1. MI + Thrombosis 2. Aneurysm + Rupture

Question 19

Clinical presentation of buerger disease ?? | p-66

Answer 19

1. Ulceration 2. Gangrene 3. Autoamputation of finger and toes 4. Raynaud phenomenon

Question 20

Raynaud phenomenon involvement in which vasculitis ?? | Pathoma-66

Answer 20

Buerger disease

Question 20

Classical presentation of kawasaki diusease ??

Answer 20

1. Fever 2. Conjunctivitis 3. Erythematous rash of plam & sole 4. Enlarged cervical lymph node 1. 5. age <4yr old asian children

Question 21

Heavy smoking association in which vasculitis ?? | P-66

Answer 21

Buerger disease

Question 22

Tx of buerger disease >?? | P-66

Answer 22

Cessation of smoking

Question 23

Tx of wegener granulomatosis ?? | P-66

Answer 23

1. Cyclophosphamide 2. Steroids

Question 23

Small vessel vasculitis examples ?? | P-66

Answer 23

1. Wegener granulomatosis 2. Microscopic polyangitis 3. Churg strauss syndrome 4. Henoch schonlein purpura

Question 24

Necrotizing granulomatous vasculitis including which site cause - Wegener Granulomatosis ?? | P-66

Answer 24

1. Nasophaynx 2. Lung 3. Kidneys

Question 25

Which serum marker in wegener granulomatosis ?? | P-66

Answer 25

c-ANCA

Question 26

p-ANCA serum level in which disease ?? | P-66

Answer 26

1. Microscopic polyangitis 2. Churg strauss syndrome

Question 27

Classical presenattion of wegener granulomatosis ??

Answer 27

1. Sinusitis 2. Nasopharangeal ulceration 3. Hemoptysis 4. Bilateral nodular lung infiltrates 5. Hematuria 6. Rapidly Progressive Glomerulonephritis

Question 28

Features of churg strauss syndrome ?

Answer 28

1. Asthma 2. Peripheral eosinophilia | P-66

Question 29

Vasculitis + IgA immune complex deposition = ?? | P-67

Answer 29

Henoch schonlein purpura

Question 29

Wegenar granulomatosis vs Microcopic polyangitis ??

Answer 29

WG -- Nasopharyngeal + granuloma present ' MP == Absent

Question 30

Henoch schonlein purpura Tx ?

Answer 30

Steroids

Question 31

Henoch schonlein purpura clinical feature ???

Answer 31

1. Palpable purpura on legs & buttoks 2. GI pain 3. Bleeding 4. Hematuria 5. IgA nephropathy 6. URT infection | P-67