Vasculitis

Question 1

Cutaneous vasculitis may be either a ___-limited disease, a ___ ____
vasculitis with secondary ____ involvement; or a cutaneous manifestation of a systemic vasculitis.

Answer 1

Cutaneous vasculitis may be either a skin-limited disease, a primary cutaneous
vasculitis with secondary systemic involvement; or a cutaneous manifestation of a systemic vasculitis.

Question 2

classifications of vasculitis

Answer 2

1. small vessel (leukocytoclastic vasculitis)
2. medium vessel: polyarteritis nodosa
3. large vessel: giant cell temrporal arteritis, takayasu’s arteritis

Question 3

which type of vasculitis more associated wtih cutaenous involvemnet?

Answer 3

small and medium vasculitis

Question 4

Vasculitis secondary to medications is usually a small vessel vasculitis known as a
____ ____ (LCV) because of the predominance of ___ on pathology

Answer 4

Vasculitis secondary to medications is usually a small vessel vasculitis known as a
leukocytoclastic vasculitis (LCV) because of the predominance of neutrophils on pathology

Question 5

morphology?

Answer 5

purpuric papules that are non-blanching, often favoring the lower legs. Lesions may be asymptomatic or painful or pruritic. Coalescing lesions will show skin
necrosis often with central pustulation.

Question 6

approach to LCV

Answer 6

complete history and physical examination to identify likely etiology and possible extracuteanous oragn system involvement

• skin biopsy looking for immune complexs
• blood worka dn look for internal organ involvement
• discontinuation if medicine is a culpret.

Question 7

what types of medications can cause cutaneous manifestations of small vessel vasculitis

Answer 7

allopurinol, sulfa-drugs, penicillin and anti-convulsants.

Question 8

treatment for cutaneous involvement in vasculitis

Answer 8

conservative unless significant cutaneous necrosis is imminent.

Extracutaneous involvement is treated with oral corticosteroids and a steroid sparing immunosuppressive agent may be needed.