VEGF pathway

Question 1

What is the primary signalling VEGFR in blood vasculature

Answer 1

VEGFR2

Question 2

What is the role of effector proteins

Answer 2

To shunt VEGF-activated receptors toward clathrin coated pits

Question 3

What is the link between VEGF and tip cell formation

Answer 3

The endothelial cell that receives the most VEGF signal will become the tip cell

Question 4

Three ways that the VEGF pathway could be inhibited

Answer 4

1. Bind to VEGF to prevent binding to receptor
2. RTK inhibitor that prevents VEGFR cross-phosphorylation
3. Blocks PTK kinase by covering ATP binding site

Question 5

What is the role of PTP1b?

Answer 5

It inhibits functioning of VEGFR2, thereby shutting down signal transduction

Question 6

What are the five VEGF proteins

Answer 6

VEGFA-D and placenta growth factor (PGF)