Warfarin

Question 1

How does it work?

Answer 1

Inhibiting an essential step in the synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X)

Question 2

How anticoagulation measured?

Answer 2

Using PT and converting into INR

Question 3

Target INR for patient on Warfarin?

Answer 3

2-4.5

Question 4

Target INR for normal patients?

Answer 4

2-3

Question 5

Drug known to potentiate the action of warfarin?

Answer 5

Thyroxine
Antibiotics (including eryhtromycin) 
Alcohol
Anti-depressants
Aspirin 
Amiodarone
Quinine

Question 6

Rx of moderately high INR with no bleeding?

Answer 6

Omit dose of warfarin

Question 7

Rx of significantly raised INR without bleeding?

Answer 7

Omid dose of warfarin

Start vitamin K PO

Question 8

Rx of of high INR with bleeding?

Answer 8

Dose of vitamin K PO or IV
Prothrombin complex concentrate e.g. Beriplex
OR
FFP