wbc production
Formation of WBCs (Leukocytes)
Stimulated by:
Colony Stimulating Factors (CSFs)
Interleukins
Source of stimulation:
These are released in response to:
Infections (e.g., bacterial toxins)
Inflammatory chemicals (e.g., histamine)
Effect:
They stimulate red bone marrow to make WBCs
They boost immune function of existing WBCs
(So they don’t just make more — they also make them stronger!)
Platelets are made when
Formation of Platelets (Thrombocytes)
Stimulated by:
Thrombopoietin (a hormone made by the liver)
Process:
Thrombopoietin tells megakaryocytes (big bone marrow cells) to fragment and release platelets.
Regulation:
Not fully understood yet — it’s known that thrombopoietin plays a major role, but the exact triggers are still being studied.
Bone marrow biopsy
Bone Marrow Biopsy
Done when there’s concern about:
Leukemia
Other bone marrow disorders
How it’s done:
A special needle draws red marrow from a flat bone (like the ilium or sternum).
Why:
The cells are examined under a microscope to check for:
Abnormal WBCs
Cancer cells
Immature or overproduced cells