What is senescence
Biological aginat the cellular and organismal legel
What comes with senescence
Increased mortality, increased risk of disease, functional decline
What is the difference betweeen gerontology and geruatrics
Gerontology the study of aging and geriatrics the health care of older people, including the study of health and disease in later life
What is primary and secondary aging
Primary is the normal aging, loss of function and all, secondary is aging due to hereditary defects and negative environmental influences
What is genomic instability
Damage to nuclear and mitochondrial dna by free radicals, radiation and mutagens
What is telomere attrition
Wearing down of the protective caps on telomeres
What is epigenetic attrition
The switch from young genes to pro aging genes
What is loss of proteostasis
Degradation of mechanical modifications of protein degrading and leaving behind harmful by products
What is deregulated nutrient snesing
The deregulation of nutrient semsing, leading to less energy created
What is mitochondrial disfuncfioning
Damage to the mitochondria resulting in lower energy production, increases oxidative stress and contamination of the mitochondria
What cellular senscence
Accumulation of senescent cells that don’t devise, impairing tissue function and increases inflamation
What is stem cell exhaustion
Depletion of stem cells resulting in weaker immune system and slower repair
What is altered intercellular communicstion
Deregulated comminication channels between cells causing increased chronic inflammation and tissue damage
What is ages
Advanced glycatiom end product
What is advanced glycation end prpduct
Reaction bw carbs and free amino groups creates cross links in long lived proteins, resulting in increased stiffness in blood vessels and joints and bladder, also impairing the function of organs
What is stoscharic epigenetic drifts
Due to advanced glycation end products it turns tissues into cellular mosaics
What comes with gradual decline of the whole system
A byproduct of advanced glycation end products, a decline in endicrine function such as estrogen and all and a decline in estrogen
