1.3

Question 1

what groups are more susceptible to adverse effects and toxicity

Answer 1

pediatric and geriatric

Question 2

when it comes to Pregnancy ADME what changes

Answer 2

A- increased absorption (gi mobility is decreased, prolonged transit = decreased dosing)
D- increased dosing
M- metabolism increased = increased dosing
E- increased GFR = increased dosing

may cause higher drug levels and prolonged drug exposure *especially if the drug crosses the placenta

Question 3

what trimester is at risk for most gross malformations (developmental defects)

Answer 3

first trimester

Question 4

what trimester is at risk for most functional malformations

Answer 4

third trimester

Question 5

drugs diffuse across the placenta =

Answer 5

highly lipid soluble