6.4

Question 1

what are Phagocytes?

Answer 1

key components of the Innate immune system

Question 2

deascribe the innate immune system

Answer 2

the way the body defends itself from Pathogens without requiring any Adaptive response
responsible for initial, immediate response to infection by patogens

Question 3

what does the Innate innate immune system include?

Answer 3

1. Physical barrier (skin, mucos)
2. circulating proteins (antimicrobial peptides)
3. Cytokines (TNFa, IL-1)
4. Innate Immune cells (Phagocytes, Natural Killer Cells)

Question 4

types of Phagocytes?

Answer 4

Neutrophils
Eosinophils
Basophils
Monocytes/ Macrophages
Dendritic cells

Question 5

what is the origin of Pagocytes?

Answer 5

Myeloid cell lineage (like RBC and Platelets)

Question 6

where do Natural killer cells originate from?

Answer 6

Lymphoid cell lineage

Question 7

How do WBC migrate to their location?

Answer 7

1. Rolling (selectins send “danger” signal)
2. Adhesion (by Integrins)
3. Transendothelial Migration (Lukocytes squeez btw endothelial cells and enter the interstitial space)
4. Migration (via Chemotaxins)

Question 8

what do the Innate immune system recognizes?

Answer 8

Pathogens-Associated Molecular Patterns (PAMPs)

Question 9

what are Pathogens-Associated Molecular Patterns

Answer 9

simple molecules/patterns present on the microorganism but not on the body’s own cells

Question 10

Examples for PAMP’s?

Answer 10

LPS
double strand RNA
b-glucans (Fungi)

Question 11

what on the Phagocyte recognize PAMP?

Answer 11

Pattern Recognition Receptors (PRR’s)

Question 12

examples for PRR’s?

Answer 12

Toll-Like-Receptor (TLR)