ARB

Question 1

MOA

Answer 1

ARB
a reversible, non-competitive, angiotensin II receptor antagonist. It deters vasoconstriction and aldosterone-secreting effects by specifically intercepting the binding of angiotensin II to the AT(1) receptor

Question 2

Drug names

Answer 2

• Candesartan
• Eprosartan
• Irbesartan
• Losartan
• Olmesartan
• Telmisartan
• Valsartan

Question 3

indication

Answer 3

• Heart failure (valsartan, candesartan)
• High coronary disease risk (losartan)
• DM
• CKD (irbesartan, losartan)

Question 4

adverse effect

Answer 4

• Hyperkalemia
• Increase in sCr (<35% acceptable)
• Angioedema (less than ACEI)
• Hypotension/syncope
• Cough
• rash

Question 5

monitoring

Answer 5

• Electrolytes (K)
• Renal function (sCr, BUN)
• 7-14 days after initiation/dose change

Question 6

comment

Answer 6

Contraindication:
• Pregnancy (avoid in 2nd/3rd trimesters)
• Angioedema
• Bilateral renal artery stenosis