loops

Question 1

MOA

Answer 1

-Inhibits reabsorption of Na+ and Cl- in the ascending loop of Henle and distal renal tubule, interfering with the chloride-binding cotransport system increased excretion of water, Na+, Cl-, Mg, and Cl

Question 2

drugs

Answer 2

• Bumetanide
• Furosemide
• Torsemide
• Ethacrynic acid

Question 3

indication

Answer 3

edema

Question 4

adverse effects

Answer 4

• Hypokalemia
• Hyponatremia
• Metabolic alkalosis
• Hyperuricemia
• Hypomagnesemia

Question 5

monitoring

Answer 5

• Electrolytes (hypo-K)
• BUN, SCr
• I & O
• 7-14 days after initiation

Question 6

comment

Answer 6

• Avoid in pts with sulfonamide allergy, except ethacrynic acid