thiazides

Question 1

MOA

Answer 1

Diuretic

• inhibits re absorption of NA+ and Cl- from distal renal tubule
• increase Ca reabsorption

Question 2

drug names

Answer 2

• chlorthalidone
• indapamide
• hydrochlorothiazide
• metolazoone

Question 3

indication

Answer 3

• HF stage A (chlorthailadone)
  -high coronary disease risk (chlorthalidone)
  -diabetes (chlorthalidone)
  stroke (peirdoril + indapamide)

Question 4

adverse effect

Answer 4

• Hypokalemia and other electrolyte imbalances
• Negative effect on glucose (intolerance; insignificant +3-5mg/dL) and lipids
• Sexual dysfunction

Question 5

comments

Answer 5

• Avoid in pts with sulfonamide allergy, except ethacrynic acid
• Chlorthalidone= 2X more potent than HCTZ
• Thiazide diuretics are more effective as anti-HTNs than loop diuretics
• Caution in pts with gout
• Ineffective when CrCl <30ml/min

Question 6

monitoring

Answer 6

• Electrolytes (hypo-K, Na & hyper-Ca)
• Uric acid
• BUN, SCr
• I & O fluids
• 7-14 days after initiation