potassium-sparing

Question 1

MOA

Answer 1

-inhibits the reabsorption of sodium in exchange for potassium and hydrogen ions by exerting a direct effect on the distal renal tubule

Question 2

drug

Answer 2

• Amiloride

Question 3

adverse effect

Answer 3

• Photosensitivity, rash (triamterene)

* Hyperkalemia, hyperuricemia

Question 4

indication

Answer 4

edema

Question 5

monitoring

Answer 5

• Potassium level

* 7-14 days after initiation

Question 6

comment

Answer 6

• K-sparing diuretics and ACEi may enhance hyperkalemic effects
• Avoid in pts with CrCl <10 ml/min