Atropine

Question 1

Etiology of Poisoning - Atropine

Answer 1

• Atropine is a Natural Alkaloid in Solanaceous Plants
• It’s a Parasympatholytic Compound that penetrates the Blood-Brain-Barrier

Question 2

Mechanism of Action - Atropine

Answer 2

• Acts as a Competitive Antagonist of Muscarinic receptors on Postganglionic endings of Parasympathetic Fibers
• Prevents binding of Acethylcholine to it receptors
• Spasmolytic effect on Smooth muscles
• Depressant effect on Secretion from Glands

Question 3

Clinical Symptoms - Atropine

Answer 3

• Facial flushing
• Dry mucous membrane => Intense thirst
• Pupils unreactive to light
• Tachycardia, Hypertension
• Disorientation, Delirium

High does of poisoning
* Hyperthermia
* Central Extraction
* Hallucination
* Fatigue
* Coma

Question 4

Treatment - Atropine

Answer 4

• Symptomatic (Mostly)
  -Beta Blockers = Tachycardia
  -Diazepam = Excitation
• Activated Charcol = Peroral poisonings
• Physostigmine = In Life Threatning Poisonings (penetrates the BBB)

Question 5

Chemical-Toxicological Analysis (CHTA) - Atropine

Answer 5

• TLC - Thin layer chromatography
  -Results: Orange or Brown spots on Yellow background

(Strass and Otto Method = Alkaloids)