Warfarin

Question 1

Etiology of poisoning - Warfarin

Answer 1

• Warfarin is the effective compoind of Rodenticides

Question 2

Mechanism of action - Warfarin

Answer 2

• It has an Anticoagulatn action
• Prevents production of Prothrombin in the Liver
• Prolongs Clotting Time
• Damages the Capillaries

Question 3

Clinical Symptoms - Warfarin

Answer 3

Cats and Dogs:
* Internal bleeding = blood may be seen in:
-Vomit
-Diarrhoea
-Urine

Other symptoms of Animals
* Bleeding from Natural openings
* Anemia
* Weak/Fast pulse
* Respiratory difficulty
* Collapse => Death (5-7 days)

• Hematomata (anywhere on the body)
• Paralysis
• Brain Hemorrhages => Sudden Death

Question 4

Treatment - Warfarin

Answer 4

• Antidote: Vitamin K or K1
• Blood transfusion

Question 5

Chemical-Toxicological Analysis (CHTA) - Warfarin

Answer 5

• TLC - Thin layer chromatography
  -Result: Blue stain on Yellow background