DNOC

Question 1

Etology of Poisoning - DNOC

Answer 1

• DNOC is used as Insecticide, Acaricide, Fungicide and Herbicide

Question 2

Mechanism of Action - DNOC

Answer 2

• Inhibition of Oxidative Phosphorylation in the Tissue
  -Causes decreased synthesis of Energy Rich Compoinds (e.g. ATP)
  -That stimulates the Metabolism in the Poisoned Organims

! It is also a Methemoglobinanemic Agent!

Question 3

Clinical Symptoms - DNOC

Answer 3

Within minutes:
* Yellow Mucous Membrane, Skin and Feathers
* Hyperpnoea, Dyspnoea
* Sweating => Increased Body Temperature
* Oliguria
* Muscle weakness, Spasms
* Rapid Rigor Mortis after Death!

Question 4

Treatment - DNOC

Answer 4

• Application of Barbiturates
• Rehydration => Offer water
• Cold room
• Decontamination of the Skin => with Sope and Water

At high concentrations:
* Methemoglobin Methylene Blue is applied

Question 5

Chemical-Toxicological Analysis (CHTA) - DNOC

Answer 5

• Extraction in Organic Dissolvents
  -For Isolation and Detection

! All materials with conspicous Yellow colour MUST be examined

-Alkaline Environment = Forms Salt - soluble in waterwith intensive Yellow colour of NaOH
-Acid Environment = Poorly soluble