Critical period
Period in which certain development happens optimally. Not impossible after but a lot more difficult. Systems are vulnerable for lesions in this period.
Major morphological abnormalities
during construction of organs, weeks 2 - 8.
neural tube defectys
Folic acid use decreases chance
Risk factors
Age of parents
Nutrition, drugs, alcohol and smoking
Stress
Mental disorder/medication
Infections
Down syndrome
Chromosomal anomalies. Trisomy 21, mental retardation and usually heart defects. Age of mother very important (after 40 large increase)
Achondroplasia (dwarfism)
Fathers age matters for this, risk increases with age. Mutation in sperm cells (not only explanation)